白细胞总数与心血管病主要危险因素的关系  

Relationship of Total White Blood Cell Count to Cardiovascular Risk Factors in Healthy Subjects

作　　者：杨冀衡[1] 陆泽元[2] 罗国辉[1] 胡雪松[1] 张东辉[1] 许香广[1] 

机构地区：[1]广东医学院附属福田人民医院心内科,广东省深圳市518033 [2]广东医学院附属福田人民医院内分泌科,广东省深圳市518033

出　　处：《中国动脉硬化杂志》2004年第5期571-573,共3页Chinese Journal of Arteriosclerosis

基　　金：深圳市科技局基金 ( 2 0 0 2 0 413 6)资助

摘　　要：为探讨白细胞总数与心血管病危险因素的关系 ,对 138例健康体检者在检测白细胞总数的同时 ,调查年龄、性别和吸烟 ,测定体质指数、腰围、腰臀比、血压、血糖、血脂、胰岛素和肿瘤坏死因子α等 ,以稳态模式的胰岛素抵抗指数评价胰岛素抵抗。结果发现 ,白细胞总数与体质指数、腰围、腰臀比、肿瘤坏死因子α、收缩压、舒张压、餐后 2h血糖、甘油三酯的对数、空腹胰岛素的对数和胰岛素抵抗指数的对数呈正相关 (均为P <0 .0 5 ) ,与高密度脂蛋白胆固醇呈负相关 (P =0 .0 0 6 ) ;以白细胞总数为因变量的多元逐步回归分析也显示仅自变量腰围、肿瘤坏死因子α和吸烟进入回归方程。提示白细胞总数与心血管病的危险因素如肥胖、餐后血糖、血压、甘油三酯。Aim To investigate the relationship between total white blood cell (WBC) Count with cardiovascular risk factors in healthy subjects. Methods The age,gender and history of smoking of 138 subjects were investigated. The body mass index (BMI),waist circumference (WC), waist to hip ratio (WHR),systolic blood pressure (SBP),Diastolic blood pressure (DBP),triglyceride (TG),total cholesterol (TC),low density lipoprotein,high density lipoprotein- cholesterol (HDLC),fasting insulin,and tumour necrosis factor-α (TNF-α) were also determined. A 75 g oral glucose tolerance test was performed in all participants. Insulin resistance was evaluated by using Homeostasis Model Assessment (HOMA). Results Total WBC count was significantly positive correlation(P<0.05) with BMI,WC,WHR,SBP,DBP,TNF-α,2 h glucose after glucose load,LnTG,LnFIns,and Ln(HOMA-IRI) (all P<0.05) and negative correlation with HDLC (P=0.006). In a multiple stepwise regression analysis,only WC,TNF-α and history of smoking were positive predictors of total WBC count after adjusting for all potentially confounding variables. Conclusion The total WBC count associates with cardiovascular risk factors such as obesity,2-h glucose after load,blood pressure,TG,HDL-C and history of smoking.

关 键 词：流行病学 白细胞总数和分类计数 危险因素 动脉粥样硬化性心血管疾病 C反应蛋白 

分 类 号：R181.3[医药卫生—流行病学]