普拉固对颈动脉粥样硬化的影响  

The Effect of Pravachol on Carotid Artery Atherosclerosis

作　　者：郑志平[1] 冷辉林 宋永建[3] 

机构地区：[1]广州市第一人民医院老年科,广东省广州市510180 [2]江西省宜春市人民医院神经内科,江西省宜春市336003 [3]上海第二医科大学附属瑞金医院神经内科,上海市200025

出　　处：《中国动脉硬化杂志》2004年第5期593-595,共3页Chinese Journal of Arteriosclerosis

摘　　要：探讨普拉固对颈动脉粥样硬化的治疗及保护作用。将 12 0例颈动脉粥样硬化并高脂血症患者随机分为对照组和治疗组 ,治疗组给予普拉固 10mg/d治疗 ,并在治疗后 3、6及 12月以彩色超声多普勒检查双侧颈动脉及复查血脂 ,观察双侧颈动脉粥样硬化斑块的数量、类型、管腔内径及颈动脉后壁内膜中膜厚度 ,与对照组进行比较。结果发现 ,普拉固治疗 3月后能有效降低血浆总胆固醇、甘油三酯和低密度脂蛋白胆固醇水平 ,升高高密度脂蛋白胆固醇水平 ,且随着治疗时间的延长 ,其斑块数量减少、类型改变、管腔内径增大和内膜中膜厚度减小均有统计学意义 (P <0 .0 5或P <0 .0 1)。结果提示 ,普拉固能有效降低血脂水平 。Aim To discuss the curative effect and protection of Pracachol on carotid atherosclerosis. Methods 120 patients with carotid atherosclerosis and hyperlipaemia were randomly divided into treatment group and control group. The treatment group were treated with Pracachol 10 mg/d and their carotids and lipid level were checked after 3, 6 and 12 months in order to compare with the control group on the numbers and types of their carotid atheromatous plaques,carotid inner diameters (D), the thickness between carotid intima-media thickness (IMT). Results 3 months' treatment with Pracachol can decrease total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDLC) level in plasme efficiently, and as the treatment prolonged, the decrease of plaques'numbers, the change of plaques' type and the dinilution of IMT all has Statistcal significance. Conclusions Pracachol can decrease the lipid level in plasma efficiently, and to some extent, it can improve and stabilize the carotid atheromatous plaque as well.

关 键 词：内科学 普拉固对颈动脉硬化的影响 超声检测 动脉粥样硬化 血脂 普拉固 

分 类 号：R5[医药卫生—内科学]