1-(取代吡唑-4-甲酰基)吡唑类化合物的合成及生物活性研究  

Synthesis and Biological Activity of Novel 1-(Substituted-pyrazole-4-carbonyl) Pyrazoles

作　　者：程永浩[1] 邹小毛[1] 高颖[1] 杨华铮[1] 

机构地区：[1]南开大学元素有机化学研究所

出　　处：《高等学校化学学报》2004年第11期2024-2027,共4页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金 (批准号 :2 0 172 0 3 1);教育部博士学科点专项基金资助

摘　　要：设计合成了 2 5个新型 1 -取代吡唑甲酰基吡唑系列衍生物 ,化合物结构经 1 H NMR、元素分析、 IR和MS确证 .生物活性测试结果表明 ,该类化合物具有一定除草活性 。A series of new 1-(substituted-pyrazole-4-carbonyl)-pyrazoles were synthesized by the reaction of 5-amino-1-methyl-3-(methylthio)-1H-pyrazole-4-carbohydrazide and 5-amino-1-methyl-1H-pyrazole-4-carbohydrazide respectively with 2-cyano-3,3-bis(alkylthio) acrylates or 2-\malononitriles. All the compounds were structurally confirmed by elemental analysis and 1H NMR. Their herbicidal activities were tested. Bioassay results showed that some of them had herbicidal activities. The structure-activity relationship was discussed, which indicated the substituents on the pyrazole ring have influence on the title compounds activities.

关 键 词：HPPD抑制剂 合成 吡唑 生物活性 构效关系 

分 类 号：O626[理学—有机化学]