武汉地区气传致敏真菌与变应性鼻炎的发病关系  

Study on the relationship of airborne sensitization fungus and anaphylactic rhinitis in Wuhan

作　　者：尹玉敏 谢利平[2] 

机构地区：[1]武汉铁路中心医院变态反应科,武汉430064 [2]武汉市第六医院耳鼻咽喉科

出　　处：《临床耳鼻咽喉科杂志》2004年第11期645-646,共2页Journal of Clinical Otorhinolaryngology

摘　　要：目的 :探讨武汉地区气传致敏真菌与变应性鼻炎的发病关系 ,以指导其预防、诊断和治疗。方法 :对门诊就医的 392例变应性鼻炎患者 (鼻炎组 )进行致敏原皮试检测 ,同时用 15种当地常见真菌进行分类皮试 ;采用酶联免疫吸附实验 (ELISA)法进行血清总IgE水平测定 ,并与 85例健康志愿者 (对照组 )比较。结果 :392例患者中 2 39例真菌皮试阳性 (6 0 .97% ) ,其阳性率明显高于对照组 (7.0 6 % ) ,χ2 =80 .4 9,P <0 .0 1;血清总IgE水平亦明显高于对照组 (t=5 .4 7,P<0 .0 1)。当地主要气传致敏真菌为根霉、弯孢霉、交链孢霉等。结论 :气传致敏真菌是变应性鼻炎的重要致敏原之一。Objective:The aim of our studies is to explore the relation between superior sensitizing fungus and anaphylactic rhinitis, for directing the prevention, dignosis and treatment of the disease.Method:Three hundred and ninty-two persons were treated by allergen skin test.Using 15 main sensitizing fungus, 90 anaphylactic rhinitis were examined.The serum levoel of IgE were examined,too.Result:In the allergen skin testing 239 cases( 60.97%) were positive, the positive rate was higher than that in contrast group(t= 5.47,P< 0.01).The main fungus allergen were Rhizopus nigricans、Cuvularia and Altevnaria , the value of IgE in patients group was higher than that in control group (t= 5.47,P< 0.01).Conclusion:It proves that airborne sensitizing fungus are important causes of anaphylactic rhinitis.

关 键 词：鼻炎 变应性 孢子 真菌 IGE 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]