复聪香液对血管性痴呆模型大鼠海马神经元的影响  

Effect of Fucongxiang Liquid on Hippocampal Neurons in Rat Models with Vascular Dementia

作　　者：余尚贞[1] 赵长鹰[2] 杜娟[3] 

机构地区：[1]暨南大学医学院附属第六医院,江门市五邑中医院江门529000 [2]暨南大学医学院附属第一医院,广州510632 [3]暨南大学医学院

出　　处：《广州中医药大学学报》2004年第5期382-384,共3页Journal of Guangzhou University of Traditional Chinese Medicine

摘　　要：【目的】 观察复聪香液对血管性痴呆大鼠海马CA1区神经元形态结构的影响。【方法】 SD大鼠40只随机分为4组,分别为假手术组、模型组、脑复康对照组和复聪香液组,经反复脑缺血再灌流加降血压法造模后,分别给予生理盐水、复聪香液及脑复康溶液,连续15 d后脑部取材,苏木素伊红(HE)染色观察海马CA1区组织形态变化。【结果】 与假手术组比较,模型组可见大量神经细胞损伤、变性,甚至坏死;而复聪香液及脑复康均能不同程度地减轻神经细胞损伤。【结论】 复聪香液对血管性痴呆模型大鼠大脑海马CA1神经元损伤具有一定的保护作用。【Objective】 To investigate the effect of Fucongxiang Liquid (FL) on hippocampal CA1 neurons in rat models with vascular dementia. 【Methods】 Forty SD rots were randomized to four groups: pseudo-operation group, model group, Naofukang group and FL group. Rat models with vascular dementia were established by repeated cerebral ischemia/reperfusion combined with decreasing blood pressure and then were given with normal saline, Naofukang and FL respectively for 15 days. After treatment, the brain of mrs was taken out to make slices for hematoxylin and eosin staining to observe the histomorphological changes of hippocampal CA1 neurons. 【Results】 As compared with the pseudooperation group, a large amount of damaged, degenerative or even necrotic neurons were fotmd in the model group; FL and Naofukang could reduce the damage of neurons to different extents. 【Conclusion】 FL exerts a protective effect on hippocampal CA1 neurons in mice models with vascular dementia.

关 键 词：复聪香液/治疗应用 痴呆 血管性/中药疗法 痴呆 血管性/病理学 疾病模型 动物 大鼠 

分 类 号：R285.5[医药卫生—中药学]