胃舒散对四氯化碳性肝损伤小鼠的影响  

Effects of Weishu Powder on Acute Liver Injury Induced by Carbon Tetrachloride in Mice

作　　者：林旭楷[1] 许森源 张奕鹏[1] 郑庭亮[1] 张薇[1] 

机构地区：[1]汕头大学医学院第二附属医院,广东汕头505041 [2]汕头市金石制药总厂,广东汕头515041

出　　处：《广州中医药大学学报》2004年第5期385-386,390,共3页Journal of Guangzhou University of Traditional Chinese Medicine

摘　　要：【目的】 观察胃舒散对四氯化碳(CCl_4)所致小鼠急性肝损伤的影响。【方法】 昆明种小鼠50只,随机分为5组,分别为正常对照组、模型组、联苯双酯组(150 mg/kg)和胃舒散高、低剂量组(4.0g/kg、2.5g/kg),各给药组分别灌胃给药,连续7 d,第8天除正常组外,其他各组小鼠经腹腔注射体积分数为0.5％CCl_4花生油溶液(10 mL/kg),16 h后测定小鼠肝质量、血清丙氨酸氨基转移酶(ALT)值、肝组织丙二醛(MDA)值及坏死灶数目。【结果】 CCl_4急性肝损伤小鼠肝质量增加(与正常组比较P<0.05),血清ALT升高(与正常组比较P<0.01),肝组织MDA水平升高(与正常组比较P<0.01),肝组织坏死灶显著增加;与模型组比较,胃舒散能降低血清ALT和肝组织MDA水平(均P<0.05),并能减少肝组织坏死病灶(P<0.05或P<0.01),但对肝质量增加无明显影响。【结论】 胃舒散对小鼠CCl_4急性肝损伤有一定程度的保护作用。【Objective】 To investigate the effect of Weishu Powder (WP) on acute liver injury induced by carbon tetrachloride (CCl_4) in mice. 【Methods】 Fifty mice were randomized to normal control group (group A), model group (group B), bifendate pills group (group C), low-dose WP group (group D) and high-dose WP group (group E). The mice in the above groups were fed with the corresponding drugs by gastric infusion for 7 days. On the 8th day of feeding, the mice except those in group A were given 0.5% CCl_4 peanut oil solution (10 mL/kg) by intraperitoneal injection. Sixteen hours later, liver weight, serum level of alanine aminotransferase (ALT), malondialdehyde (MDA) content and necrotic focus amount in the liver were observed. 【Results】 As compared with the normal group, liver weight, serum ALT level and necrotic focus amount were increased in model mice with CCl_4-induced acute liver injury (P<0.05 or P<0.01). WP could decrease serum ALT level and hepatic MDA content (P<0.05), reduce the necrotic focus amount (P<0.05 or P<0.01) but had no effect on the increase of liver weight. 【Conclusion】 WP has a protective effect on mice with CCl_4-induced acute liver injury.

关 键 词：胃舒散/治疗作用 肝/损伤 疾病模型 动物 小鼠 

分 类 号：R285.5[医药卫生—中药学]