通肺合剂对慢性阻塞性肺疾病夜间低氧血症的干预作用  

Intervention Effect of Tongfei Mixture on Nocturnal Hypoxia in Patients with Chronic Obstructive Pulmonary Disease

作　　者：崔朝勃[1] 袁雅冬[2] 刘淑红[1] 韩东亮[1] 高秀玲[1] 齐富存[1] 

机构地区：[1]河北衡水哈励逊国际和平医院,河北053000 [2]河北医科大学第二医院

出　　处：《中国中西医结合杂志》2004年第10期885-888,共4页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：河北省衡水市科技局资助项目 (No .0 30 1 0A)

摘　　要：目的探讨以当归、生地等 14味中药组成的通肺合剂对慢性阻塞性肺疾病 (chronicobstructivepulmonarydisease ,COPD)夜间低氧血症的疗效。方法选择 60例COPD缓解期患者 ,随机分为 3组 ,对照组 (A组 ) 2 0例 ,单纯氧疗组 (B组 ) 2 0例 ,通肺合剂加氧疗组 (C组 ) 2 0例 ,观察 3组患者治疗前后肺功能、膈肌移动度 (diaphragmmusclemobility ,DMM )、6分钟步行距离 ( 6minuteswalkdistace,6MWD)、晨起动脉血气、夜间最低氧饱和度 (LSaO2 )、平均血氧饱和度 (MSaO2 )、血氧饱和度 <90 %时间占总睡眠时间百分比(SLT90 %)及超声心动图的改变。结果治疗后B组和C组LSaO2 、MSaO2 及SLT90 %明显高于A组 (P <0 0 5 ,P <0 0 1 )。第 1秒时间肺活量 (FEV1 )、6MWD、DMMC组与A组及B组比较有改善 ,差异有显著性(P <0 0 5 ) ;PaO2 、SaO2 B组、C组与A组治疗后比较有明显改善 ,差异有显著性 (P <0 0 5 ) ;C组PaCO2 与B组比较明显降低 ,差异有显著性 (P <0 0 5 ) ;C组与B组、A组比较肺动脉平均压 (mPAP)下降 ,差异有显著性 (P <0 0 5 )。结论通肺合剂加氧疗除能改善夜间低氧血症 ,还能降低PaCO2 。Objective To study the effect of Tongfei mixture (TFM, a Chinese recipe mainly consisted of angelica and rehmannia root) on nocturnal hypoxia in patients with chronic obstructive pulmonary disease (COPD). Methods Sixty patients with COPD of remission phase were randomly divided into 3 groups, 20 in each group. Group A was the control group; Group B, the group simply treated with oxygen; Group C, treated with oxygen and TFM. Changes of pulmonary function, diaphragm muscle mobility (DMM), 6 min walk distance (6MWD), morning arterial blood gas, nocturnal lowest oxygen saturation (LSaO 2), mean blood oxygen saturation (MSaO 2), the percentage of saturation lower than 90% time account for total sleeping time (SLT90%) and ultrasonocardiogram before and after treatment were observed. Results Levels of LSaO 2, MSaO 2 and SLT 90% in Groups B and C were significantly higher than those in Group A (P<0.05,P<0.01). The lowering of PaCO 2 in Group C was more significant than that in Group B (P<0.05). The mPAP level in Group C was lower, FEV 1, 6MWD and DMM were improved than those in Group A and B, showing significant difference (P<0 05). Conclusion Combined use of oxygen therapy and TFM could not only improve the nocturnal hypoxia, but also lower PaCO 2. TFM is an important supplement of oxygen therapy.

关 键 词：夜间低氧血症 氧疗 合剂 慢性阻塞性肺疾病 治疗后 PACO2 血氧饱和度 显著性 差异 结论 

分 类 号：R259[医药卫生—中西医结合]