^(131)I治疗Graves’病后甲状腺γ射线的体外测定和分析  

Thyroid γ ray measurement after iodine-131 therapy for Gr aves’ disease

作　　者：刘剑锋[1] 郭庆玲[1] 叶根耀[1] 李欣[1] 王安瑜[1] 王英[1] 祝辉[1] 何玲[1] 袁超[1] 

机构地区：[1]军事医学科学院附属医院,北京100039

出　　处：《军事医学科学院院刊》2004年第5期467-468,共2页Bulletin of the Academy of Military Medical Sciences

摘　　要：目的 :了解Graves’病患者服用放射性13 1I治疗后 2 4h内甲状腺对13 1I的吸收情况。方法 :Graves’病患者18人 ,根据服用的13 1I剂量分为A组 (小剂量组 ) ,服用13 1I剂量平均在 16 2 .8MBq(4.4mCi) ;B组 (大剂量组 ) ,服用13 1I剂量平均在 2 5 5 .3MBq(6 .9mCi) ,空腹服用13 1I后行 1,2 ,4 ,8,12 ,2 4h 6个时间点的甲状腺体外γ射线剂量率的测定。结果 :空腹服用13 1I后 1hγ射线剂量率快速增高 ,2～ 12h为高峰持续期 ,随后缓慢下降 ,B组的高峰出现时间较早 ,曲线波动明显高于A组 (P <0 .0 0 1) ,但两组的曲线形态大致相同。结论 :Graves’病患者服用13 1I后1h是甲状腺快速吸收和浓聚期 ,12h后缓慢代谢和释放 ,不同的个体甲状腺吸收13 1I的过程有所差异。Objective:To study the thyroid 131 I uptake w ithi n 24 hours following 131 I therapy for Graves’ disease. Meth od s: Eighteen hyperthyroidism patients were divided into two groups ac cording to thyroid weight and radiotherapy dosage.Low-dose group and high-dos e group received the mean dose 162.8 MBq (4.4 mCi)and 255.3 MBq( 6 9 mCi ),respectively. The γ ray dose rates from thyroids were measured in all patie n ts at 1,2,4,8,12 and 24 h after 131 I therapy. Results: γ Ray dose rates were elevated rapidly at 1 hour and continued at high lev el between 2-12 h and slowly fell in 24 h after 131 I therapy. γ Ra y curve of low-dose group was lower than that of high-dose group. Con clusion: There was a rapid absorption and concentration period in 1 h and slow metabolism and release period after 12 h in thyroid following radioio dine therapy of Graves’ disease. The thyroids of hyperthyroidism patients displ ayed different γ ray curves.

关 键 词：^131I 格雷夫斯病 Γ射线 

分 类 号：R581.1[医药卫生—内分泌]