唐古特大黄多糖对大鼠应激性胃溃疡的保护作用  

Protective effects of Rheum tanguticum polysaccharides on stress induced by gastric ulcer in rats

作　　者：曹晓林[1] 刘莉[1] 王志鹏[1] 刘振国[1] 梅其炳[1] 

机构地区：[1]第四军医大学基础部药理学教研室

出　　处：《中国临床药理学与治疗学》2004年第10期1115-1118,共4页Chinese Journal of Clinical Pharmacology and Therapeutics

摘　　要：目的探讨唐古特大黄多糖(Rheumtanguticumpolysaccharides,RTP)对大鼠应激性胃溃疡的保护作用。方法用水浸束缚应激法(waterimmersionandrestraintstress,WRS)复制大鼠应激性胃溃疡模型,提前灌胃给予大黄多糖,应激6h后处死动物,观察溃疡指数和胃粘膜损伤程度的变化,检测血清及胃粘膜组织中超氧物歧化酶(SOD)和丙二醛(MDA)的变化。结果RTP能明显降低应激大鼠胃粘膜溃疡指数和胃粘膜MDA水平,升高血清和胃粘膜SOD活性。结论RTP对水浸束缚应激引起的大鼠应激性胃溃疡有明显的保护作用,可能是大黄治疗应激性胃溃疡的有效成分之一。AIM: To evaluate the protective effects of Rheum tanguticum polysaccharides (RTP) on stress induced by gastric ulcer in rats. METHODS: Water immersion and restraint stress (WRS) induced gastric injury was used as the experimental model of acute gastric ulcer. Rats were orally administrated with RTP before stressed. 6 hours after WRS, all the animals were sacrificed and the stomachs of rats were taken out to examine the ulcer index and observe histologically. The activity of total superoxide dismutase (SOD) and malondialdehyde (MDA) were measured in serum and gastric mucosa. RESULTS: Six hours of water immersion and restraint stress (WRS) resulted in appearance of acute gastric mucosal lesions. RTP significantly decreased the ulcer index and the level of MDA in mucosa of stressed rats, and increased the activity of SOD both in serum and gastric mucosa. CONCLUSION: RTP has remarkable protective effects on WRS induced gastric ulcer in rats, which suggests that the effective component of rhubarb on stress induced by gastric injury is perhaps RTP.

关 键 词：应激 溃疡 唐古特大黄多糖 丙二醛 超氧 化物歧化酶 

分 类 号：R285.5[医药卫生—中药学]