感通颗粒抗感冒作用的实验研究  

Experimental study of anti-cold effects of gantong granules

作　　者：张晓慧 [1] 谢湘林 [2] 周鸣 [1] 李璐 [3] 

机构地区：[1]长春中医学院附属医院国家药品临床研究基地,长春,130021,吉林 [2]吉林大学药学院 [3]长春中医学院

出　　处：《中国临床药理学与治疗学》2004年第10期1187-1189,共3页Chinese Journal of Clinical Pharmacology and Therapeutics

摘　　要：目的观察感通颗粒对鼠非特异性炎症及免疫性炎症和解热止痛作用影响。方法采用小鼠耳壳炎症模型、大鼠足肿胀和棉球肉芽组织增生模型观察抗炎作用,另外观察小鼠非特异性免疫功能及解热镇痛作用。结果感通颗粒能抑制小鼠二甲苯所致小鼠耳壳炎症和角叉菜胶所致的大鼠足肿胀,减轻大鼠棉球肉芽组织的重量,提高小鼠对碳末廓清指数和吞噬指数,并具有解热止痛、增强机体免疫力的功能。结论感通颗粒具有明显的消炎和抗感冒作用。AIM: To observe anti cold effects of the gantong granules in animals, such as inflammatory, febrifuge and relieving pain. METHODS: Some animal models were used to investigate the anti inflammation, immunity functions of the gantong granules, including the auricular inflammation models, the feet swelling test, the cotton ball granulating proliferation test, the carbon particle clearance index test, hemolytic and febrifuge test, and lymphocyte counts. RESULTS: The gantong granules inhibited the auricular inflammation induced by dimethylbenzene in mice and the feet swelling induced be carrageenin in rats, and decreased the weights of cotton ball granulation tissues in rats. It also showed an increase in carbon particle clearance index K value and phagocytic index value in mice. Moreover it relieved pain with febrifuge, and potentiated the cellular immunity. CONCLUSION: The gantong granules show remarkable antiinflammatory effects and resistance to the cold.

关 键 词：感通颗粒 炎症 免疫功能 感冒 动物模型 

分 类 号：R285.5[医药卫生—中药学]