动态监测SARS病人IL-1α、IL-1β、TNFα和IL-6含量及其意义  

Dynamic observation IL-1α,IL-1β,TNFα and IL-6 of patients with severeac ute respiratory syndrome

作　　者：黄宪章[1] 王建兵[1] 丁海明[1] 罗福东[1] 庄俊华[1] 林琳[2] 

机构地区：[1]广东省中医院二沙岛分院检验科,广州510105 [2]广东省中医院内三科,广州510120

出　　处：《中国免疫学杂志》2004年第11期777-779,共3页Chinese Journal of Immunology

基　　金：国家中管局中医药科技非典专项资助项目 (0 8号 );广东省中医药局科研课题 (2 0 3 0 15 )

摘　　要：目的 :动态监测SARS病人IL 1α、IL 1β、TNFα和IL 6含量并探讨其意义。方法 :采用酶联免疫吸附法定量检测早期、恢复期SARS病人以及出院后SARS随访者 ,一线未患SARS健康医护人员及健康体检者血清中IL 1α、IL 1β、TNFα和IL 6含量。结果 :IL 1α和IL 1β含量在早期、恢复期与其他组比较均显著升高 (P <0 0 5 )。SARS早期组TNFα均值显著高于其他组(P <0 0 0 5 ) ,SARS恢复期组均值显著高于SARS随访组、急诊等一线未患SARS组和健康对照组 (P <0 0 1)。SARS早期组IL 6均值显著高于其他各组 (P <0 0 0 5 ) ,SARS随访组与急诊等一线未患SARS组和健康对照组间均值比较 ,均有显著差异 (P <0 0 1)。结论 :SARS在发病过程中其病理损伤与细胞因子IL 1、TNFα和IL 6有关。Objective:Dynamic observation IL-1α,IL-1β,TNFα and IL-6 of patients with Severe Ac ute Respiratory Syndrome(SARS) and to explore its significance. Methods:IL-1α,IL-1β,TNFα and IL-6 were determined in SARS patients during the fi rst, recovery and follow-up stage, the front health doctors,nurses and health p eople. Results:The means of IL-1α and IL-1β during the first and recovery stage were signif icant higher than that of other groups(P<0.05).The means of TNFα during th e first stage was higher than that of other groups(P<0.005) and the mean of recovery stage was higher than that of follow-up stage, the front health docto rs, nurses and health people(P<0.01). The mean of IL-6 during the first st age was higher than that of other groups(P<0.005) and the mean of follow-u p stage was higher than that of the front health doctors, nurses and health peop le(P<0.01). Conclusion:The pathological injury in pathogenesis of SARS is related to cytokines, such as IL-1, TNFα and IL-6. [

关 键 词：严重急性呼吸综合征 白细胞介素1Α 白细胞介素1Β 肿瘤坏死因子α 白细胞介素6 

分 类 号：R563.1[医药卫生—呼吸系统]