五例氨基糖甙类抗生素致聋家系报道  

Investigation of five families with aminoglycoside antibiotics-induced deafness

作　　者：曹菊阳[1] 白琳娜 冀飞[1] 申卫东[1] 张农香 袁慧军[1] 

机构地区：[1]解放军总医院耳鼻咽喉研究所,北京100853 [2]江西省残联康复部,南昌330008

出　　处：《中国听力语言康复科学杂志》2004年第6期15-17,共3页Chinese Scientific Journal of Hearing and Speech Rehabilitation

摘　　要：目的 本文报导了5个药物性耳聋家系,耳聋患者大都有明确的氨基糖甙类抗生素应用史。研究小组赴当地访问了五个家系共28名成员,对所有受访者进行了全身体检、耳鼻咽喉专科检查、纯音测听、声导抗及听性脑干诱发电位检查,其中有12人为中重度感音神经性听力下降,听力图为高频曲线型中的高频陡降型为主,未见其他系统的异常改变。遗传图谱分析显示,五个家系均符合母系遗传特征,提示为线粒体遗传方式。五个家系共采集了23名成员的静脉血样,这些临床资料的收集,为我们下一步进行致聋基因突变的分析奠定了良好的基础。Five families with Aminoglycoside Antibiotics-induced deafness were reported . In thesefive families, most patients with hearing loss had an obvious history of aminoglycoside antibiotics application.28 family members have received physical examination, pure-tone audiometry, immittance testing and auditorybrainstem response testing (ABR). The results indicated that 12 of 28 tested family members had senso-rineural hearing loss in various degrees. No associated visible abnormalities in other systems were foundamong the families. The mode of inheritance of those familise should be matrilineal according to thepedigrees. The full collections of both blood samples and physiological hearing assessments have provided thesolid basis for future study on mutation screening.'

关 键 词：药物性耳聋 氨基糖甙类抗生素 母系遗传 家系 

分 类 号：R595.3[医药卫生—内科学]