6-硝基-1,2-重氮氧基-4-萘磺酸及其杂质的高效液相色谱分析  

Determination of 6-Nitro-l,2-diazoxynaphthalene-4-Sulfonic Acid and Its Impurities by High Performance Liquid Chromatography

作　　者：李春梅[1] 

机构地区：[1]沈阳化工研究院,沈阳110021

出　　处：《染料与染色》2004年第5期298-300,303,共4页Dyestuffs and Coloration

摘　　要：本文以反相高效液相色谱对6-硝基-1,2-重氮氧基-4-萘磺酸及有机杂质进行了分析。选择了流动相、离子对、检测波长,研究了不同牌号ODS C18色谱柱的重现性,得到了6-硝基-1,2-重氮氧基-4-萘磺酸及杂质(1,2-重氮氧基-4-萘磺酸、8-硝基-1,2-重氮氧基-4-萘磺酸)的相关系数分别为:0.99956、0.99991、0.99317;标准偏差和变异系数分别为:0.214250％、0.016890％、0.564557％、0.012695％、0.488467％、0.014560％。得到了准确度数据,确定了最小检出量。6-Nitro-l,2-diazoxynaphthalene-4-Sulfonic Acid and other organic impurities were analyzed by the reversed-phase HPLC; the mobile phase, ion pair and detecting wavelength were selected, the reproducibility of different makers of ODS C18 was studied. At the optimumseparatingconditions, the correlation coefficients of6-Nitro-1,2-diazoxynaphthalene-4-SulfonicAcid, 1,2-diazoxynaphthalene-4-Sulfonic; 8-Nitro-l,2-diazoxynaphthalene-4-Sulfonic, were 0.99956,0.99991, and 0.99317 respectively, the standard deviations and coefficients of variation being 0.21425%, 0.01689%; 0.564557%, 0.012695% and 0.488467%, 0.01456% respectively. The precision accurate data made available and the minimum amount for determination was set.

关 键 词：6-硝基-1 2-重氮氧基-4-萘磺酸 1 2-重氮氧基-4-萘磺酸 8-硝基-1 2-重氮氧基-4-茶磺酸 反相高效液相色谱 

分 类 号：O657.7[理学—分析化学]