电针、氟西汀治疗抑郁症前后血小板膜鸟苷酸结合蛋白含量的变化  

Effects of Fluoxetine and Electroacupuncture on G-protein Level in Platelet Membrane from Patients with Major Depression

作　　者：宋煜青[1] 周东丰[1] 范建华[1] 罗和春[1] 赵学英[1] 

机构地区：[1]北京大学精神卫生研究所,100083

出　　处：《中国心理卫生杂志》2004年第11期783-786,共4页Chinese Mental Health Journal

基　　金：国家自然科学基金 (批准号 39870 951 )

摘　　要：目的 :探讨电针与抗抑郁药治疗抑郁症对中枢神经系统信号传导通路G蛋白的作用。方法 :符合DSM -IV抑郁症诊断标准的抑郁症患者 78例 ,分别接受电针、氟西汀和安慰剂治疗 (例数分别为 2 4,2 4,3 0 ) 6周 ,对治疗前后患者血小板膜G蛋白各亚型的含量采用蛋白印记方法进行测定。结果 :抑郁症患者治疗前Gαi、Gαq含量均大于正常对照 (P =0 0 0 1,P =0 0 0 0 ) ,Gαs含量与正常对照无差异 (P =0 72 3 )。氟西汀、电针和安慰剂治疗不能改变抑郁症的Gαi ,Gαq的高水平状态。三种治疗对Gαq蛋白的亚型的含量没有影响。结论 :抑郁症患者的G蛋白存在异常 ,Gαi和Gαq高水平状态可能是抑郁症的特征性指标 。Objective: Affective disorder patients can be effectively treated by electro-acupuncture methods without many side effects, but the mechanism of the treatment is not known. The object of this study was to discover whether there is change of guanine-nucleotide-binding protein (G-protein) level in platelets membrane from major depression patients before and after treatment by fluoxetine and electro-acupuncture. Methods:We utilized selective antibodies to quantitate the levels of the G-protein α subunits in platelets membrane of 78 major depression patients (24 received fluoxetine treatment, 24 received electo-acupuncture treatment and 30 received placebo treatment) and 30 matched comparison subjects.Result:Levels of both Gαi and Gαq of the patient groups were higher than matched normal comparison subjects before treatment of fluoxetine and electro-acupuncture,the level of Gαi and Gαq did not change after the treatment of fluoxetine, electro-acupuncture and placebo. The level of Gαs wasn't significantly different with matched comparison subjects.Conclusion:The levels of Gαi、Gαq in platelets membrane from major depression patients are higher than normal, the high levels of Gαi and Gαq in platelets membrane may be a trait abnormality for major depression patients, not a state abnormality for major depression.

关 键 词：治疗 抑郁症患者 电针 含量 氟西汀 血小板膜 G蛋白 高水平 结论 变化 

分 类 号：R749[医药卫生—神经病学与精神病学] R735.7[医药卫生—临床医学]