二水一碘羧酸根合铂(II)混配配合物的合成及其抗肿瘤活性  

Synthesis and antitumor activities of diaqua platinum(II) complexes with carboxylates and iodo.

作　　者：张金超[1] 龚钰秋[1] 郑小明[1] 杨梦苏[2] 崔景荣[3] 

机构地区：[1]浙江大学化学系 [2]香港城市大学生物及化学系 [3]北京大学天然药物及仿生药物国家重点实验室,北京100083

出　　处：《浙江大学学报（理学版）》2004年第6期642-645,660,共5页Journal of Zhejiang University（Science Edition）

基　　金：浙江省自然科学基金资助项目(298068);北京大学医学部天然药物及仿生药物国家重点实验室资助项目(0310-3096789).

摘　　要：首次合成四种二水一碘羧酸根合铂类配合物[Pt(II)(H2O)2I(OCOR)](I～IV)(R=—C6H4NO2,—C6H4NH2,—CH2Cl,—CHCl2).用元素分析、摩尔电导、差热热重分析、红外光谱、紫外光谱和核磁共振氢谱对其进行了表征.体外抗肿瘤活性表明,四种配合物对所试的肿瘤细胞表现出较低的活性,只有在10μM浓度下配合物才仅对某些肿瘤细胞有一定的增殖抑制作用.The complexes of the type\ (I^IV)(R=—C_6H_4NO_2,—C_6H_4NH_2,—CH_2Cl,—CHCl_2) were synthesized for the first time. They were characterized by elemental analysis, molar conductance, differential thermal analysis and spectral(IR, UV, ()~1HNMR) studies. The results indicated that complexes I^IV had poor activities against human tumor cell lines in vitro and only have limited antiproliferative effects against some human tumor cell lines at concentration of 10 μM.

关 键 词：混胺铂类配合物 合成 抗肿瘤活性 

分 类 号：O614.121[理学—无机化学]