哮喘患者微量元素与ECP和IL-5关系的研究  

The Study of the Relation between Microelemente and Cytokine in Asthma Patients

作　　者：吴琦[1] 朱宝玉[1] 刘阳[1] 

机构地区：[1]天津医科大学总医院呼吸科,300052

出　　处：《天津医药》2004年第11期661-662,共2页Tianjin Medical Journal

摘　　要：目的:探讨哮喘患者血清微量元素与嗜酸细胞阳离子蛋白(ECP)和白细胞介素5(IL-5)的关系。方法:同步检测18～65岁哮喘患者的肺功能、血清微量元素(Zn,Cu,Fe,Mg,Se)和ECP水平。结果:Cu和Cu/Se与FEV1呈负相关,与ECP呈正相关;Cu/Se与IL-5呈正相关;Se与ECP呈负相关;FEV1与ECP及IL-5均呈负相关。结论:哮喘患者血清微量元素Cu,Se及Cu/Se与血清细胞因子IL-5,ECP和FEV1密切相关。哮喘是慢性的气道炎症过程。Objective: To explore the relationship between serum microelements and cytokines in asthma patients. Methods: Measure the serum levels of microelements, ECP and FEV1 in asthma patients aged 18～65. Results: Serum levels of Cu and the ratio of Cu/Se were negatively related to FEV1, and positively related to the serum levels of ECP. The ratio of Cu/Se was positively related to the IL-5 levels in PBMC. Serum levels of Se was negatively related to the serum levels of ECP. Serum levels of Cu, the ratio of Cu/Se, serum levels of ECP and IL-5 levels in PBMC were all negatively related to FEV1. Conclusions: Serum levels of Cu, Se, and the ratio of Cu/Se, were all closely related to FEV1, IL-5 levels in PBMC and serum ECP.

关 键 词：ECP IL-5 哮喘患者 FEV1 血清微量元素 白细胞介素5 血清细胞因子 负相关 结论 正相关 

分 类 号：R562.25[医药卫生—呼吸系统] R725[医药卫生—内科学]