去氢骆驼蓬碱在小鼠的抗炎镇痛及止痒作用  

Anti-inflammatory,Analgesic and Antipruritic Effects of Harmine

作　　者：陈蔚如[1] 张海丽[2] 张岩[2] 冯英进[1] 

机构地区：[1]中国民航学院航空医学教研室,300300 [2]南开大学医学院药理室

出　　处：《天津医药》2004年第11期681-683,共3页Tianjin Medical Journal

基　　金：新疆维吾尔自治区科委资助项目(项目编号:G9531007)

摘　　要：目的:观察去氢骆驼蓬碱的抗炎、镇痛及止痒作用。方法:以二甲苯鼠耳致炎及角叉菜胶致小鼠足跖肿胀观察抗炎作用;以小鼠扭体反应及热板法观察镇痛作用;以右旋糖酐-40致小鼠全身瘙痒模型观察药物止痒作用。结果:去氢骆驼蓬碱以剂量依赖的方式显著抑制鼠耳肿胀,在25mg/kg显著抑制足跖肿胀;剂量依赖地减少发生扭体反应的鼠数,提高小鼠的痛阈;明显抑制小鼠全身瘙痒的发作次数及发作持续时间。结论:去氢骆驼蓬碱具有抗炎、镇痛及止痒作用。Objective: To observe the anti-inflammatory, analgesic and antipruritic effects of harmine (Har), a alkaloid extracted from seeds of Peganum harmala. Methods: The anti-inflammatory effects were detected with xylene-induced ear swelling and carrageenan hind paws edema in mice. The acetic acid writhing test and 55℃ hot plate test in mice were used to detect the analgesia, and the itch-scratch responses were induced by Ⅳ dextran-40 in mice. Results: The Har inhibited mouse ears edema significantly in a dose-dependent manner. The mouse hind paws edema was decreased significantly at 25 mg/kg, which lasted over five hours. Har reduced the mouse number of writhing and raised mouse pain threshold in a dose-dependent manner. Har also significantly decreased paroxysm frequeney and the duration of the itch. Conclusions: The Har possess anti-inflammatory, analgetic and antipruritic effects.

关 键 词：小鼠 去氢骆驼蓬碱 止痒作用 观察 抗炎镇痛 扭体反应 全身瘙痒 结论 方式 目的 

分 类 号：R285.5[医药卫生—中药学] R284.1[医药卫生—中医学]