蒙古族高血压者血管紧张素转换酶基因多态性与胰岛素抵抗及血脂的关系(英文)  

Relationship of polymorphism of angiotensin-converting enzyme gene and insulin resistance and blood lipid in Mongolian hypertensives

作　　者：刘丽娟[1] 叶宏[1] 佟伟军[2] 刘国玉[3] 李永山 黄桂蓉[1] 王健[3] 张永红[2] 

机构地区：[1]哈尔滨医科大学公共卫生学院流行病学教研室,黑龙江省哈尔滨市150001 [2]苏州大学放射医学与公共卫生学院流行病学教研室,江苏省苏州市215007 [3]通辽市疾病预防控制中心检验科,内蒙古自治区通辽市028000 [4]科左后旗卫生防疫站流行病科,内蒙古自治区科左后旗028100

出　　处：《中国临床康复》2004年第33期7585-7587,共3页Chinese Journal of Clinical Rehabilitation

基　　金：国家自然科学基金资助项目(30040040)~~

摘　　要：背景:血管紧张素转换酶(angiotensin-convertingenzyme,ACE)基因被认为是高血压发生的候选基因,而胰岛素抵抗及高血脂也被认为与高血压的发生有关联。由于基因的遗传异质性,因此有必要在不同民族间的高血压者中探讨血管紧张素转换酶与胰岛素抵抗和血脂之间的关系。目的:探讨蒙古族高血压人群ACE基因I/D多态性与胰岛素抵抗及血脂的关系。设计:现况调查。单位:哈尔滨医科大学公共卫生学院流行病学教研室,苏州大学放射医学与公共卫生学院流行病学教研室,通辽市疾病预防控制中心检验科,科左后旗卫生防疫站流行病科。对象:选择内蒙古自治区通辽市科左后旗朝鲁吐苏木(乡)作为研究现场,所有研究对象均为在此长期居住的蒙古族居民,共获得有高血压者115例。干预:应用聚合酶链式反应检测血管紧张素转换酶基因的插入/缺失多态性,血脂、血糖和胰岛素采用试剂盒检测。主要观察指标:血脂、血糖、胰岛素、胰岛素敏感指数。结果:在115例高血压者中,II基因型者33例,ID基因型者62例,DD基因型者20例。在三组人群中总胆固醇分别为(5.1±1.4),(5.2±1.5)和(4.9±1.1)mmol/L,三酰甘油分别为(3.4±2.5),(3.4±3.0)和(2.9±1.8)mmol/L,高密度脂蛋白分别为(1.3±0.7),(1.2±0.6)和(1.3±0.9)mmol/L,低密度脂蛋白分别为(3.1±1.4),BACKGROUND:Angiotensin-converting enzyme(ACE) gene is considered one of the candidate genes of hypertension.Moreover,insulin resistance and high blood lipid are considered to be related to hypertension.Because of the genetic heterogeneity,it is necessary to study the association between ACE gene polymorphism and insulin resistance and blood lipid in hypertensives of different nationalities. OBJECTIVE:To investigate the association between insertion/deficiency(I/D) polymorphism of ACE gene and insulin resistance and blood lipid in Mongolian hypertensives. DESIGN:A study of epidemiological prevalence. SETTING:Department of Epidemiology,Public Health College of Harbin Medical University;Department of Epidemiology,Radiation Medicine and Public Health College of Suzhou University;Department of Clinical Laboratory,Center of Prevention and Control of Diseases in Tongliao City;Department of Epidemiology,Public Health Station and Epidemic Prevention of Kezuohouqi.PARTICIPANTS:The present study was conducted with inhabitants lived in Chaolutusumu Country, Kezuohouqi in Tongliao City,Inner Mongolia.Totally 115 hypertensives were selected. INTERVENTIONS:I/D polymorphism of ACE gene was measured by polymerase chain reaction, and blood lipid, blood glucose and insulin were tested with kit.MAIN OUTCOME MEASURES:Blood lipid, blood sugar, insulin and insulin sensitivity index.RESULTS:Among the 115 hypertensives,33 were with II genotype,62 with ID genotype and 20 with DD genotype.In the three groups, total cholesterol(TC) was(5.1±1.4),(5.2±1.5) and(4.9+1.1) mmoL/L respectively;trioleate glyceryl was(3.4±2.5),(3.4±3.0) and(2.9±1.8) mmoL/L respectively;High density lipoprotein(HDL) was(1.3±0.7),(1.2±0.6) and(1.3±0.9) mmoL/L respectively;Low density lipoprotein(LDL) was(3.1±1.4),(3.4±1.4) and(3.0±1.2) mmoL/L respectively.There was no significant difference among groups(P >0.05).Blood glucose was(5.5±1.1),(5.9±2.1) and(5.4±0.6) mmoL/L respectively.There was no significant difference among groups(P >0.05).Insulin level wa

关 键 词：高血压 ACE基因 胰岛素 蒙族 

分 类 号：R544.1[医药卫生—心血管疾病]