TGF-β_1和p27^(kip1)在女性生殖道尖锐湿疣中的表达  

Expression of Transforming Growth Factor-β_1(TGF-β_1 ) and p27^(kip1) in Lesion of Condyloma Acuminatum

作　　者：王远菊[1] 张洪文[2] 张志胜[2] 王新[2] 

机构地区：[1]河南焦作煤业集团中央医院妇产科,454150 [2]中南大学湘雅二医院妇产科,410011

出　　处：《中国误诊学杂志》2004年第7期1005-1007,共3页Chinese Journal of Misdiagnostics

摘　　要：目的 :探讨 TGF- β1 和 p2 7kip1在尖锐湿疣 (CA)发病机制中的作用。方法 :采用免疫组化 SP法检测 4 0例CA(外阴 CA和宫颈 CA各 2 0例 )损害中 TGF-β1 和 p2 7kip1 的原位表达 ,并以 15例健康男性正常包皮组织及 15例女性正常宫颈组织作为对照。结果 :研究组和对照组 TGF-β1 表达阳性率无显著差异 (P>0 .0 5 ) ,但 CA组 TGF-β1 过度表达率显著高于对照组 (χ2 =6 0 .92 6 ,P<0 .0 0 1) ;p2 7阳性表达率 CA组低于对照组 ,有统计学差异 (P<0 .0 5 ) ,CA组 p2 7阴性表达率明显高于对照组 (χ2 =32 .2 78,P<0 .0 0 1) ;CA组中 TGF- β1 与 p2 7kip1表达负相关 (Spearman系数 ,- 0 .0 0 9,P<0 .0 0 1)。结论 :TGF-β1 过度表达和 p2 7kip1 缺失表达可能与 CA皮损细胞增生有关。Objective:To investigation the roles of TGF- a1 and p27^(kip1) in pathogenesis of condyloma acuminatum (CA).Method:The expressions of TGF- a1 and p27^(kip1) in situ in the lesions of 40 patients (20 vulvar CA and 20 cervical CA) were examined by immunohistochemical assay; and 15 normal prepuce tissues and 15 normal cervical specimens were treated as control.Result:There was no difference in TGF-β_1 expression (P>0.05) between two groups,but the overexpression rate of TGF- β_1 in CA group were significantly higher than that in the controls (χ~2=60.926,P<0.001) .Positive rate of p27^(kip1) in CA group was lower than that in the controls (P<0.05) . Rate of absent expression of p27^(kip1) in CA group was significantly higher(χ~2=32.278,P<0.001).Inverse relationship was found in expression of TGF-beta 1 and p27^(kip1) in CA group(r=-0.900,P<0.001).Conclusion:The data suggested that overexpression of TGF-a1 and absent expression of p27^(kip1) might induce proliferation of keratinocytes in the pathogenesis of CA.

关 键 词：尖锐湿疣/病因学 生殖器疾病 女(雌)性/病因学 转化生长因子β/代谢 细胞包周期蛋白质类/代谢 

分 类 号：R711.702[医药卫生—妇产科学]