铁皮枫斗晶对小鼠辐射损伤的防护作用  

RESEARCHES ON RADIOPROTECTIVE EFFECTS OF DENDROBIUM

作　　者：王崇道[1] 强亦忠[2] 崔凤梅[1] 

机构地区：[1]苏州大学放射医学研究所,215007 [2]苏州大学医学生物技术研究所

出　　处：《辐射防护》2004年第6期403-405,408,共4页Radiation Protection

基　　金：国防科工委国防预研项目 (Y5 5 7316 2 - 5 )资助

摘　　要：研究了铁皮枫斗晶对6 0 Coγ射线一次性全身照射后小鼠主要脏器中脂质过氧化物 (LPO)和外周血中白细胞和血小板的变化以及不同剂量的铁皮枫斗晶对小鼠 3 0天存活率的影响。结果显示 ,铁皮枫斗晶能使受照后小鼠主要脏器中LPO含量明显下降 (p <0 .0 1 ) ,外周血中血小板显著升高 (p<0 .0 5 ) ;白细胞也有增高趋势 ;不同剂量的铁皮枫斗晶都能不同程度地提高受照鼠 3 0天存活率 ,说明铁皮枫斗晶具有较好的抗辐射作用。Effects of Dendrobium on the LPO content in the mouse tissues,the white blood cells and platelets in the mouse peripheral blood after whole-body γ-ray in radiation exposure were studied. Besides,the 30-day surviva1 rates of irradiated mice treated with three different doses of Dendrobium were observed. The results show that Dendrobium was effective in reducing the LPO contents in the tissues(p<0.0l);and could increase the platelets in the peripheral blood of irradiated mice;the white blood cells had a tendency toward rising;different doses of Dendrobium could raise the survival rates of irradiated mice and prolong the survival duration.The above-mentioned findings suggest that Dendrobium has the radioprotective effect and its mechanism probably relates to scavenging of free radicals and restoration of hamatopoiesis. (

关 键 词：小鼠 不同剂量 血小板 LPO 外周血 防护作用 脏器 铁皮 增高 作用原理 

分 类 号：R285[医药卫生—中药学]