慢性心力衰竭红细胞L-精氨酸/一氧化氮系统的变化  

Change of L-Arg/NO System in Erythrocytes of Chronic Heart Failure

作　　者：彭雯[1] 成蓓[1] 张秀娥[1] 张湖萍[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院老年病科,湖北武汉430022

出　　处：《中国误诊学杂志》2004年第5期661-663,共3页Chinese Journal of Misdiagnostics

摘　　要：目的 :探讨慢性心力衰竭 (CHF)患者红细胞 L-精氨酸 (L- Arg) /一氧化氮 (NO)系统的变化。方法 :实验分为 CHF组 (n=2 5 )和对照组 (n=2 0 )。通过核素标记测定红细胞 3H- L- Arg转运的特征 ;一氧化氮合酶 (NOS)改良法测定红细胞 NOS活性。结果 :CHF组红细胞 L- Arg摄入总转运 Vmax及 Y+通道介导的转运 Vmax较正常对照组明显增加 ,Km两组无明显差异。 Y+ L通道介导的转运 Vmax与正常组无变化 ,Km较正常组下降 ,红细胞 NOS生成量及 NOS活性均增加。结论 :CHF时红细胞膜上 Y+ 通道介导的 L-Objective:To study the change of L-Arg/NO system in erythrocytes of chronic heart failure.Methods:45 people were divided into two groups: CHF group(n=25) and Control group(n=20). The 3H-L-Arg transport, NO synthase (NOS) production and NOS activity were measured.Results:The V max for total transport of L-Arg via system Y + increased in erythrocytes of CHF compared with control subjects,while the Vmax for the transport of L-Arg via system Y +L was unaffected in erythrocytes of CHF. Km values for total L-Arg influx via Y +system were not significantly different in two groups.Conclusions:The activity of L-Arg transport via system Y was increased in CHF.

关 键 词：心力衰竭 充血性/血液 红细胞/化学 精氨酸/血液 一氧化氮/血液 

分 类 号：R541.610[医药卫生—心血管疾病]