异丙酚靶控输注不同麻醉深度下兔脑区NO/cGMP水平的改变  

Alteration of NO and cGMP Levels in Discrete Brain Regions of Rabbit under Different Anesthetic Depths by Using Target-Controlled Infusion

作　　者：陈建颜[1] 姚尚龙[2] 王祖音[1] 

机构地区：[1]广东省深圳市第二人民医院麻醉科,518035 [2]华中科技大学同济医学院附属协和医院麻醉科,湖北武汉430022

出　　处：《中国误诊学杂志》2004年第5期667-669,共3页Chinese Journal of Misdiagnostics

摘　　要：目的 :研究异丙酚不同全麻深度下不同脑区 NO、c GMP水平的改变。方法 :日本大耳兔 30只 ,随机分为 3组 ,对照组、浅麻醉组、深麻醉组各 10只 ,应用异丙酚靶控输注系统 ,观察异丙酚不同麻醉深度下大脑皮层、海马、小脑NO,c GMP含量。结果 :随着异丙酚麻醉深度的增加 ,异丙酚呈剂量依赖性抑制小脑内 NO/ c GMP信号转导通路。异丙酚同样抑制海马 ,皮层 NO/ c GMP信号转导通路 ,但 NO/ c GMP水平的改变并未随着麻醉深度的加深而进一步下降。结论 :异丙酚通过降低 NO,c GMP水平 ,抑制兴奋性神经传递和增强抑制性神经传递 ,从而发挥麻醉作用。异丙酚对 NO/cObjective:To explore alterations of NO and cGMP levels in discrete brain regions of rabbit during propofol anesthesia.Methods:Thirty rabbits were randomly divided into three groups with ten each:control group,light anesthetic group,deep anesthetic group. By using target-controlled infusion of propofol, the levels of NO and cGMP in cerebral cortex, hippocampus, cerebellum were observed under different anesthetic depths.Results:With the increase of anesthetic depth, propofol significantly depressed NO/cGMP signal transduction pathway in cerebellum in a dose-dependent manner. Propofol also depressed NO/cGMP signal transduction pathway in cerebral cortex?hippocampus, but the levels of NO and cGMP were not decreased further with the increase of anesthetic depth.Conclusions: Propofol exerted its anesthetic action through decreasing the levels of NO and cGMP,disrupting excitatory pathways of neurotransmitter and simultaneously enhancing inhibitory neurotransmitter pathways .This kind of depression differed in different brain regions.

关 键 词：二异丙酚 脑/药物作用 一氧化氮/分析 环GMP/分析 

分 类 号：R614.1[医药卫生—麻醉学]