蒙药清热八味散(额日赫木-8)对SARS的临床研究  

Effect of Erihemu-8 on SARS

作　　者：张汉丰[1] 马国强[1] 郝富[1] 汪立勤 李继平[1] 兰助晴 李秀峰[1] 

机构地区：[1]内蒙古自治区医院呼吸内科,内蒙古呼和浩特010017 [2]内蒙古生产力促进中心,内蒙古呼和浩特010010

出　　处：《内蒙古医学杂志》2004年第10期732-734,共3页Inner Mongolia Medical Journal

基　　金：内蒙古科技厅资助课题课题号 2 0 0 3 0 6 0 2

摘　　要：目的 :观察蒙药额日赫木— 8对SARS的临床疗效。方法 :对照组 2 1例 ,给以抗病毒 ,预防感染 ,免疫调节 ,营养支持 ,对症治疗 ;治疗组 2 1例 ,在上述治疗基础上加用蒙药额日赫木— 8,3g/次 ,2次 /日 ,冲服 ,疗程 10d。观察两组SARS患者治疗前后的发热、头痛、全身疼痛、乏力、咳嗽、胸痛、呼吸困难、腹泻 ;白细胞计数 (WBC) ,淋巴细胞总数 (LC) ,血小板计数 (PT) ,血尿素氮 (BUN) ,血肌酐 (Cr) ,谷丙转氨酶 (ALT) ,谷草转氨酶 (AST) ;动脉血氧饱和度 (SaO2 ) ;胸部X线检查 17项指标。结果 :①治疗组较对照组发热天数平均缩短 2 0d ,组间差异有显著性意义 ,P <0 0 5 ;且体温改善疗效积分 2 31± 0 6 0 ,较对照组 1 4 0± 0 6 4,组间差异有显著性意义 ,P <0 0 0 1。②治疗组动脉血氧饱和度 (SaO2 ) ,治疗前后组内差异有显著性意义 ,P<0 0 5。③两组间胸部X线阴影改善积分治疗组优于对照组 ,组间差异有显著性意义 ,P <0 0 5。结论 :对本组SARS病人研究结果显示 :在西药治疗的基础上加服蒙药额日赫木— 8对缩短发热周期 ,改善机体缺氧 ,促进肺部阴影吸收有一定的效果 ,其机理有待进一步临床验证。Objective:To investigate the clinical efficacy of Erhemu8 Mongolia traditional medicine on severe acute respiratory syndrome (SARS).Methods:21 SARS patients in Control group were treated with anti-virus,antibiotic,immunization and allowance of nutrients,etc.21 SARS patients in treatment group were treated with both Erihemu-8 (3g 2 times daily for ten days)and the above medicines.17 parameters of subjects in two groups are investigated before and after treatment.The parameters are provided for symptom with fever,headache,pantalgia,fatigue,cough,chest pain,short breath,palpitation;and the test of white cell count (WBC),lymphatic cell count (LC),platelet count (PT),blood urea nitrogen (BUN),creatinine (Cr),alamine aminotransferase (ALT),aspartate aminotransferase (AST),oxygen saturation (SaO 2),chest x-ray. Results:①The results have shown that the average days of lasting fever were decreased two days in the treatment group than those in the control group (P<0.05).The therapeutic score of temperature improvement in treatment group (2.31±0.60) was much higher than that in control group (1.40±0.64),showing significant difference(P<0.001).②The SaO 2 in treatment group was significantly diffrent before and after the treatment (P<0.05).③The improved score of image by the chest x-ray examination in treatrrent group was prior to that in control group(P<0.05).Conclusion:The results have shown that the Mongolia traditional medicine,Erihemu-8 combined with western medicine can improve fever time,hypoxia and absorption of pulmorary foci.Its mechanism needs further identified in the clinical practice.

关 键 词：蒙药 对照组 治疗组 发热 SARS 动脉血氧饱和度 治疗前后 显著性 意义 差异 

分 类 号：R563.1[医药卫生—呼吸系统] R291.2[医药卫生—内科学]