分离产金属β-内酰胺酶的铜绿假单胞菌  

Isolation of Metallo-β-lactamase-producing Pseudomonas aeruginosa from An Inpatient Setting

作　　者：沈定霞[1] 罗燕萍[1] 崔岩[1] 赵莉萍[1] 白立彦[1] 

机构地区：[1]解放军总医院,北京100853

出　　处：《中华医院感染学杂志》2004年第1期86-88,共3页Chinese Journal of Nosocomiology

摘　　要：目的　检测我院内科某病区产金属 β-内酰胺酶的铜绿假单胞菌及其对抗菌药物的耐药性。方法　纸片法测定产金属 β-内酰胺酶的铜绿假单胞菌 ;微量稀释法测定其对抗菌药物的耐药性。结果　该病区产金属 β-内酰胺酶的铜绿假单胞菌占同期分离铜绿假单胞菌的 32 .3% ,产酶菌株对替卡西林 /克拉维酸、头孢哌酮、头孢他啶、头孢吡肟、亚胺培南、奈替米星 ,复方增效磺胺耐药 ;对阿米卡星敏感 ;对哌拉西林、哌拉西林 /他唑巴坦、环丙沙星、洛美沙星部分敏感。结论　产生金属 β-内酰胺酶是铜绿假单胞菌对头孢类及碳青酶烯类耐药的机制之一 ,实验室对其正确检测可帮助临床合理选用抗菌药物并减少耐药性的扩散。OBJECTIVETo detect the metallo-β-lactamase-producing Pseudomonas aeruginosa (PA) and its resistance to antimicrobial agents. METHODSDisk method and microdilution test were used. RESULTSMetallo-β-lactamase-producing PA accounted for 48.4% in all PA isolates. They were all resistant to ticarcillin/clavulanic acid, cefoperazone, ceftazidime, cefepime, imipenem, netilmicin, and trimethoprim/sulfamethoxazole, susceptible to amikacin, partly resistant to piperacillin, piperacillin/tazobactam, ciprofloxacin, and lomefloxacin. CONCLUSIONSProduction of metallo-β-lactamase is one of the resistance mechanisms of PA to cephems and carbapenems. Correct detection in laboratory is important for application of antimicrobial agents and reduction of the spread of bacterial resistance.

关 键 词：铜绿假单胞菌 Β-内酰胺酶 耐药性 

分 类 号：R378.991[医药卫生—病原生物学]