SARS患者并发多器官功能障碍的临床分析  

Clinical analysis of multiple organ dysfunction syndrome in patients suffering from SARS

作　　者：阴赤贞宏 王超[1] 汤哲[2] 文艳[1] 张淑文[1] 王宝恩[1] 

机构地区：[1]首都医科大学附属北京友谊医院,北京100050 [2]首都医科大学宣武医院

出　　处：《中国危重病急救医学》2004年第11期646-650,共5页Chinese Critical Care Medicine

基　　金：北京市科技计划重大项目 (H0 2 0 92 0 0 5 0 2 3 0 )

摘　　要：目的　对严重急性呼吸综合征 (SARS)患者的相关器官功能障碍进行分析 ,探讨 SARS患者并发多器官功能障碍综合征 (MODS)的因素。方法　回顾性分析 135例 SARS和 13例并发 MODS的 SARS住院患者的临床资料。结果　 SARS可导致器官功能障碍 ,主要有急性呼吸窘迫综合征 (ARDS)、免疫系统损伤、心脏损害、肝功能损害、MODS等 ,发生率越高 ,病情越重 ,病死率越高。 SARS引起 MODS时 ,病死率高达92 .3% ,主要表现为 ARDS(76 .9% )、免疫系统损伤 (92 .3% )、心血管功能障碍 (30 .8% )、凝血功能障碍(6 1.5 % )、肝功能损伤 (38.5 % )和肾功能障碍 (5 3.8% )等。结论　 SARS相关器官功能障碍与病情发展及预后密切相关。 SARS并发 MODS可能与 SARS病毒所致免疫损伤、全身炎症反应综合征等有关。Objective To analyze the features of organ dysfunction in severe acute respiratory syndrome(SARS) and the factors inducing multiple organ dysfunction syndrome(MODS) in these patients. Methods The clinical data of 135 SARS patients and 13 patients with severe SARS complicated by MODS were studied retrospectively. Results SARS could result in organ dysfunction. Its incidence rate was high, the patients' condition was severe, and the mortality was higher. SARS could end in MODS and the mortality was 92 3%. The main dysfunctioning organs were the lung(76 9%), the immune system (92 3%) , the cardiovascular system(30 8%), the blood system(61 5%), the liver(38 5%), and the kidney (53 8%) . Conclusion Dysfunction of organs are closely correlated with prognosis of SARS. The causes of MODS in SARS are probably injury to the immune system and systemic inflammatory response syndrome.

关 键 词：严重急性呼吸综合征 多器官功能障碍综合征 临床分析 

分 类 号：R511.9[医药卫生—内科学]