不同壳聚糖降解产物与锌(Ⅱ)络合物的合成及性能表征  

The Synthesis and Characteristic of Degradation Produces on Different Molecular Weight Chitosan with Zinc Complex

作　　者：郎惠云[1] 蔡健[1] 魏永锋[1] 

机构地区：[1]西北大学化学系,西安710069

出　　处：《分析化学》2004年第11期1505-1508,共4页Chinese Journal of Analytical Chemistry

基　　金：陕西省自然科学基金资助项目 (No .0 1JK0 73 ;0 2B0 9)

摘　　要：采用H2 O2 降解的方法 ,得到了一系列不同分子量的壳低聚糖 (CTS) ,研究了降解产物对Zn 的吸附行为 ,结果表明 :在 4 0℃下 ,pH =5 ,Zn 初始浓度为 2 g/L时 ,CTS对Zn 的吸附量随着分子量的增加而增大 ,当CTS的分子量增加到一定值时 ,吸附量趋于稳定。并通过元素分析、UV、IR等方法对壳低聚糖 Zn 络合物进行了表征。探索了壳低聚糖 Zn 络合物对肾功能衰竭和尿毒症患者血液中存积的主要毒性物质———尿素的吸附行为 ,结果表明 :不同分子量的CTS Zn 络合物对尿素的吸附量大致相同 ,分子量为5 0 0 0 0、10 0 0 0 0、780 0 0 0的CTS Zn 络合物其最大吸附量分别为 85 .6、84 .3和 84 .0mg/L。CTS Zn 对尿素的吸附效果优于目前临床使用的一些吸附材料。A series of Chitosan (CTS) with different molecular weight (MW) were obtained using H2O2 as degrading reagent, and the adsorptive behavior of the degraded chitosan to Zn(II) was studied. Experiments showed, the adsorption capacity increased with the increase of the MW of the chitosan at beginning and then reached a plateau at 40degreesC and pH 5.0 when the initial concentration of Zn(II) is 2.0 g/L. The complex of chitosan-Zn(II) was prepared and characterized by elementary analysis, ultraviolet-visible spectroscopy and infrared spectroscopy. Meanwhile the adsorptive behavior of the complex to urea in the blood of kidney failure and uraemia patient was investigated. The result showed the average adsorption capacity for urea is 85.61, 84.32 and 83.97 mg/g for the chitosan of 50,000, 1000,000 and 780,000 MW respectively, the capacity is higher than the other adsorptive materials in clinical use.

关 键 词：壳聚糖 锌(Ⅱ)络合物 合成 H2O2降解 吸附 尿素 尿毒症 肾功能衰竭 

分 类 号：O641.4[理学—物理化学]