液基细胞学结合HPV检测在宫颈癌筛查中的应用价值  

Liquid-based cytologic screening and human papillomavirus assessment to detect cervical carcinoma

作　　者：罗淑贞[1] 李清[1] 刘军[1] 卢义生[1] 黄素然[1] 付莉萍[1] 郭健[1] 袁锦玉[1] 

机构地区：[1]东莞市人民医院,广东东莞523018

出　　处：《西部医学》2004年第4期307-308,共2页Medical Journal of West China

摘　　要：目的　评价液基细胞学 (Autocyte prep L CT)结合人乳头状瘤病毒 (HPV)检测对宫颈癌筛查的作用。方法应用液基细胞学、HPV检测筛查方法与宫颈活检对照 ,比较 2种方法对宫颈鳞状上皮内高度病变 (HSIL ,CIN - )和鳞状细胞癌 (SCC)筛查的准确性。结果　液基细胞学检 15 0 5 4例 ,其中 2 33例与宫颈活检诊断符合率 :HSIL (CIN - )83.3% (4 5 / 5 4例 ,含 SSC19例 ) ,SCC10 0 % (9/ 9)。并对 2 33例中的 12 4例进行 HPV- DNA检测 ,HPV16 ,18感染表现 ,慢性炎→扁平湿疣→尖锐湿疣→ CIN→宫颈癌 ,随宫颈病变加重而逐渐升高。结论　液基细胞学结合 HPV检测对宫颈癌的筛查准确性高 。Objective To evaluate the action of liquid-based (LB) technology (Autocyte prep Test, LCT) and human papillomavirus (HPV) assessment in screening vaginal carcinoma. Methods We used LB cytologic and HPV methods to detect the samples. The results were compared with cervical biopsy in terms of the accuracy of screening high-grade squamous-intraepithelial lesion,cervical intraepithelial neoplasiaⅡ-Ⅲ, and squamous cell carcinoma.Results The coincidental rate between these methods and biopsy was 83.3%(45/54)for high-grade squamous-intraepithelial lesion and cervical intraepithelial neoplasiaⅡ-Ⅲ, and 100%(9/9)for squamous cell carcinoma. The rate of HPV infection escalated with the exacerbation of the cervical lesions. Conclusion Autocyte prep LCT and HPV measurement are the good methods for screening cervical carcinoma.

关 键 词：官颈癌 液基细胞学 筛查 人乳头状瘤病毒 

分 类 号：R446[医药卫生—诊断学] R737.33[医药卫生—临床医学]