高位硬膜外阻滞术治疗扩张型心肌病患者相关白细胞介素水平的变化  

Change of some interleukins in patients with DCM after TEB

作　　者：辛晓敏[1] 李秀玉[1] 刘凤岐[2] 关秀茹[1] 李洁[1] 

机构地区：[1]哈尔滨医科大学第一临床学院检验科,150001 [2]哈尔滨医科大学第一临床学院心血管内科,150001

出　　处：《中华检验医学杂志》2004年第10期660-662,共3页Chinese Journal of Laboratory Medicine

基　　金：黑龙江省"十五"科技攻关项目 (GB0 1C12 6 0 3 )

摘　　要：目的　探讨高位硬膜外阻滞术 (TEB)治疗前后扩张型心肌病 (DCM )患者白细胞介素6 (IL 6 )、可溶性白细胞介素 2受体 (sIL 2R)和白细胞介素 10 (IL 10 )的变化。方法　TEB治疗组 2 2例、常规治疗组 13例 ,用ELISA方法测血清IL 6、sIL 2R和IL 10水平 ,比较TEB组和常规治疗组治疗前后IL 6、sIL 2R及IL 10水平的变化。结果　TEB组治疗后血清IL 6和sIL 2R水平明显降低(P =0 0 0 6 2 ,P =0 0 2 6 6 ) ,而IL 10水平有明显升高 (P =0 0 0 4 3)。结论　TEB治疗对细胞因子有良好的调节作用 。Objective To observe the change of serum IL-6、sIL-2R and IL-10 in patients with DCM after TEB treatment.Methods The serum IL-6, sIL-2R and IL-10 levels were assayed by ELISA in TEB group(n=22)and control group(n=13).Alteration of cytokines of TEB group and control group after treatment were observed.Results Serum levels of IL-6、sIL-2R were significantly depressed in patients with DCM after TEB treatment(P=0.006 2,P=0.026 6), but the level of IL-10 was significantly elevated(P=0.004 3).Conclusion TEB can regulate cytokines well and DCM may be treated by immune system regulation.

关 键 词：常规治疗 SIL-2R IL-10 扩张型心肌病 高位硬膜外阻滞 患者 治疗前后 水平 结论 变化 

分 类 号：R542.2[医药卫生—心血管疾病] R759.1[医药卫生—内科学]