大容量全肺灌洗治疗重度肺泡蛋白沉积症五例分析  

Large-volume whole lung lavage in the treatment of severe pulmonary alveolar proteinosis

作　　者：闻胜兰[1] 吴晓虹[1] 应可净[1] 周畔[1] 洪武军[1] 

机构地区：[1]浙江大学医学院附属邵逸夫医院呼吸内科,杭州310016

出　　处：《中华结核和呼吸杂志》2004年第9期598-600,共3页Chinese Journal of Tuberculosis and Respiratory Diseases

摘　　要：目的　评价大容量全肺灌洗治疗重度肺泡蛋白沉积症的临床疗效及安全性。方法采用全身麻醉下双腔气管插管 ,大容量分次肺泡灌洗 ,负压回收灌洗液并记录出入量 ,计算回收率。以患者症状的改善及胸片或胸部CT及肺功能、动脉血气的改变评价疗效。结果　 5例患者的症状均得到明显改善 ,胸片显示大部分阴影消失 ,肺功能及动脉血气有明显好转。 5例患者无一例出现严重并发症。结论　大容量全肺灌洗治疗重度肺泡蛋白沉积症疗效高。Objective To evaluate the efficacy and safety of large-volume whole lung lavage in the treatment of severe pulmonary alveolar proteinosis(PAP). Methods Five severe PAP patients underwent large-volume whole lung lavage under general anaesthesia using a double lumen endotracheal tube. Suction was used for returning fluid. The volume of lavage and return volume and the return rate were calculated. The efficacy was evaluated according to the improvement of symptoms,amelioration of chest radiograph or chest CT scan and the changes of pulmonary function and artery blood gas analysis. Results After lavage,the symptoms,pulmonary function and artery blood gas were markedly improved,and the chest radiographs showed dissipation of lung consolidation. No severe complications were observed in the 5 cases. Conclusion(Large-)volume whole lung lavage is an effective and safe therapeutic method in the treatment of PAP.

关 键 词：治疗 全肺灌洗 肺泡蛋白沉积症 重度 患者 动脉血气 胸片 结论 目的 记录 

分 类 号：R563.9[医药卫生—呼吸系统]