神经妥乐平治疗糖尿病神经病变的多中心研究  

Multicenter, randomized, positive controlled clinical study for the effects of nerotropin on diabetic neuropathy

作　　者：宁光[1] 邹大进[2] 刘伟[3] 刑惠莉[4] 张炜[1] 赵咏桔[1] 鲁瑾 徐华[3] 金杰[4] 

机构地区：[1]上海第二医科大学附属瑞金医院内分泌代谢科上海市内分泌代谢病临床医学中心上海市内分泌代谢病研究所,200025 [2]上海第二军医大学附属长海医院内分泌科 [3]上海第二医科大学附属仁济医院内分泌科 [4]上海第二医科大学附属新华医院内分泌科

出　　处：《中华医学杂志》2004年第21期1785-1787,共3页National Medical Journal of China

基　　金：上海市教委重点学科建设经费 ( 2 0 0 1)资助项目 (部分 )

摘　　要：目的　评价神经妥乐平治疗 2型糖尿病周围神经病变的疗效及安全性。方法　上海地区 4家医院的 95例糖尿病神经病变患者入选本研究 ,并随机进入神经妥乐平组 (4 9例 )和弥可保组(4 6例 )。神经妥乐平组每天 1次静脉推注神经妥乐平针剂 ,每次 2支 ;2周后口服神经妥乐平片 ,每次 2片 ,每天 2次 ,共 2周。弥可保组每天 1次肌肉注射弥可保针剂 ,每次 1支 ;2周后口服弥可保片剂 ,每次 1片 ,每天 3次 ,共 2周。结果　经 4周治疗后 ,2组的痛觉VAS评分皆有明显降低 ,神经妥乐平组治疗 1周时的有效率 (显著改善 +改善 )为 6 7 3%、显著改善率为 10 2 % ,均明显高于弥可保组 (有效率为 34 8% ,显著改善率为 2 2 % )。至 4周时 ,2组的有效率分别为 87 0 %和 6 8 5 %。神经妥乐平组麻木症状改善有效率为 5 8 7% ,弥可保组为 6 9 5 % ,神经妥乐平组显效率 (2 3 9% )明显高于弥可保组 (13 0 % )。结论　神经妥乐平对 2型糖尿病神经损害的自发性疼痛、麻木有较好疗效 ,尤其对疼痛的疗效优于弥可保组。Objective To estimate the effects of Neurotropin in the treatment of neuralgia and numbness in type 2 diabetes mellitus patients with diabetic peripheral neuropathy (DPN), and compare with Methycobal Methods Ninty five patients with DPN from 4 hospitals in shanghai were randomly assigned to two groups:49 cases in Neurotropin group ( 6 ml, IV, QD for 2 weeks, then, 2 tablets, BID for another 2 weeks) 46 cases in Methycobal group( 1 ml, IM, QD for 2 weeks, then, 1 tablet TID for another 2 weeks Results Neurotropin significantly improved neuralgia in type 2 diabetes mellitus with DPN, the efficacy rate was 67 3% in the first week, and 87 0% in the 4th week, comparing with 34 8% and 68 5% in the control group The efficacy rate for numbness was 58 7% in the study group after 4 weeks therapy, and 69 5% in control group In the whole 4 weeks therapeutic course, neuralgia and numbness were improved in the two groups, and the improved rate in Neurotropin group is high than in the control group( P <0 01) Conclusion Neurotropin had good effects in the treatment of diabetic neuralgia and numbness , the efficacy of Neurotropin in improving the senses of neuralgia is better than Methecobal , and similar with Methecobal in treating numbness

关 键 词：神经妥乐平 弥可保 治疗 有效率 糖尿病神经病变 麻木 多中心研究 上海地区 改善 针剂 

分 类 号：R587.1[医药卫生—内分泌]