DXS6804/DXS9896/GATA144D04基因座在中国汉族群体中的遗传多态性及其法医学应用  

Genetic Polymorphism of 3 STR Loci on Chromosome X and Its Forensic Application in Chinese Population

作　　者：应斌武[1] 石美森[1] 邓建强[1] 李英碧[1] 吴谨[1] 颜静[1] 张霁[1] 侯一平[1] 

机构地区：[1]四川大学华西基础医学与法医学院法医物证教研室,成都610041

出　　处：《遗传》2004年第5期603-606,共4页Hereditas（Beijing)

基　　金：国家自然科学基金(批准号30271446);高校博士点专项科研基金(批准号20020610044)~~

摘　　要：为了调查X染色体上DXS6804、DXS9896和GATA144D04等3个STR基因座在中国汉族群体的遗传多态性及其法医学应用价值,来用PCR和聚丙烯酰胺凝胶电泳对X染色体3个STR基因座进行分型,并检验女性基因型频率分布是否符合Hardy Weinberg平衡,计算法医学常用各种概率。DXS6804、DXS9896和GATA144D04的非父排除率分别为0 5990、0 6220、0 4280,表明3个STR基因座在中国汉族群体均具有遗传多态性,χ2检验表明女性的基因型频率分布符合Hardy Weinberg平衡。X染色体上的基因座DXS6804、DXS9896和GATA144D04在中国汉族群体中具有较高的遗传多态性,可应用于法医学检验和群体遗传学分析。To investigate the genetic polymorphisms of three short tandem repeats loci of chromosome X in Chinese Han population in Chengdu area and its use in forensic science. Three X-chromosome linked short tandom repeat loci were analyzed by PCR followed by polyacrylamide gel electrophoresis. Hardy-Weinberg equilibrium was tested and forensic interested value was calculated.The power of exlcution of DXS6804、DXS9896和 GATA144D04 is 0.5990、0.6220、0.4280,respectively. The result showed that all the three STR loci were polymorphic among 100 unrelated females and 120 unrelated males from Chinese Han population. χ~2 tests demonstrated that genotype frequencies in females did not depart from Hardy-Weinberg equilibrium. Three X-chromosome linked short tandem repeat loci have high polymorphism,they can be applied to forensic medicine and population genetics.

关 键 词：X染色体 短串联重复序列 遗传多态性 中国汉族 

分 类 号：Q987[生物学—遗传学]