视黄类受体与视黄酸致畸作用关系  

Relations between the Retinoic Acid Acceptor and Teratogenesis of Retinoids

作　　者：李增刚[1] 孙开来[1] 

机构地区：[1]中国医科大学遗传教研室

出　　处：《遗传》2004年第5期735-738,共4页Hereditas（Beijing)

基　　金：国家973项目资助(001CB510301)~~

摘　　要：视黄酸(维甲酸)可引起包括人在内的多种动物胚胎畸形,其生物活性是由一系列视黄酸受体及其配体介导的。其中视黄类受体RAR起主要作用,RAR的配体为强致畸物,相对致畸活性由强至弱依次为配体α、配体β和配体γ。视黄酸受体RXR的配体无致畸活性,但是可加强RAR激动剂的某些致畸郊应。视黄酸受体还可通过其它基因的表达而影响胚胎发育。视黄类受体基因突变和不同视黄类受体及其配体与致畸作用的关系,以及此类受体对其它基因表达的调节作简要综述。Retinoic acid can induce teratogenesis of the fetus of many animals including human,and its biological activities are induced by a serious of different retinoic acid accepters and their ligands.The retinoic acid acceptor RAR plays key roles in the teratogenesis,and the legands of RAR are strong teratogens.The intensity sequence of the relative teratogenesis is ligandα、ligandβ and ligandγ.The ligands of the retinoic acid acceptor RXR cannot induce teratogenesis,but they can enhance the teratogenesis of the RAR stimulus.The retinoic acid acceptors can also affect the development of the fetus by adjusting the expression of the other genes.The relations between the gene mutation of the retinoic acid acceptor,various retinoic acid acceptors and their ligands and teratogenesis of retinoic acid are summarized in this article.In addition,the regulations of the retinoic acid acceptors to the other genes are also discussed.

关 键 词：视黄类受体 视黄酸 致畸作用 

分 类 号：R114[医药卫生—卫生毒理学]