胃黏膜异型增生微观辨证分型CdX2基因表达及随访研究  被引量：4

lationship between microcosmic distinguish type of gastric dysplasia and the expression of CdX2 and its significance in follow-up study</em> <p class='article-op'> <span id="bdshare" class="bdshare_t bds_tools get-codes-bdshare baidufx"><span><span class="bds_more" style="display: block; width: 62px; height: 29px; background: url(/images/share.gif) no-repeat!important; padding: 0;"></span></span></span> </p> <p class="article-source"> <a href ='/article/read.aspx?id=10880167' class='btnTitle btnIsView' target='_blank'><img alt='在线阅读' src='/images/btn-read.png'/></a><a class='btnTitle btnIsView' href="javascript:showdown('jJg9rRnRGA7YhMgwIWzBC8eQKkifGDCxqTiM8tJj11o=')"><img alt="下载全文" src="/images/btn-down.png" /></a> <input id="hiddowninfo" type="hidden" value="jJg9rRnRGA7YhMgwIWzBC8eQKkifGDCxqTiM8tJj11o="/> </p> <div class="collect" style="display: none"> <h5>我的收藏</h5> <div class="cnt"> <p> 名 称：<input type="text" name="collTitle" id="collSumTitle" /> </p> <p> 注 释：<input type="text" 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title='刘杰[2]'>刘杰[2]</a> <a href='/writer/article.aspx?id=100000006895512' target='_blank' ><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=A%3d%5b%e8%83%a1%e5%ae%b6%e9%9c%b2%5d' title='胡家露[2]'>胡家露[2]</a> <a href='/writer/article.aspx?id=100000006461362' target='_blank' ><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=A%3d%5b%e5%ae%8b%e7%a6%8f%e6%9e%97%5d' title='宋福林[1]'>宋福林[1]</a> <a href='/writer/article.aspx?id=100000010621119' target='_blank' ><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=A%3d%5b%e9%99%86%e5%ae%87%e5%b9%b3%5d' title='陆宇平[1]'>陆宇平[1]</a> <a href='/writer/article.aspx?id=100000011502017' target='_blank' ><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=A%3d%5b%e9%99%88%e5%b1%b1%e6%b3%89%5d' title='陈山泉[1]'>陈山泉[1]</a> <a href='/writer/article.aspx?id=100000008474399' target='_blank' ><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=A%3d%5b%e6%9d%a8%e5%8d%93%5d' title='杨卓[1]'>杨卓[1]</a> <em> </em></p><p class='organ'><strong>机构地区：</strong><a href='/organ/article.aspx?id=2376&subid=&showname=&searchtype=' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=S%3d%e6%b2%88%e9%98%b3%e5%86%9b%e5%8c%ba%e6%80%bb%e5%8c%bb%e9%99%a2%e4%b8%ad%e5%8c%bb%e7%a7%91' title='[1]沈阳军区总医院中医科,沈阳110016'>[1]沈阳军区总医院中医科,沈阳110016</a> <a href='/organ/article.aspx?id=60905&subid=&showname=&searchtype=' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=S%3d%e7%ac%ac%e5%9b%9b%e5%86%9b%e5%8c%bb%e5%a4%a7%e5%ad%a6%e5%85%a8%e5%86%9b%e6%b6%88%e5%8c%96%e7%97%85%e7%a0%94%e7%a9%b6%e6%89%80' title='[2]第四军医大学全军消化病研究所'>[2]第四军医大学全军消化病研究所</a> <em> </em></p><p class='from'><strong>出　　处：</strong><a href='/journal/summary.aspx?gch=98320A' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=J%3d%5b%e4%b8%ad%e5%9b%bd%e4%b8%ad%e8%a5%bf%e5%8c%bb%e7%bb%93%e5%90%88%e6%b6%88%e5%8c%96%e6%9d%82%e5%bf%97%5d' title='中国中西医结合消化杂志'>《中国中西医结合消化杂志》</a>2004年第5期257-259,共3页<em>Chinese Journal of Integrated Traditional and Western Medicine on Digestion</em></p><p class='fund'><strong>基　　金：</strong>国家自然科学基金资助项目(No.89170024)</p><p class='abstrack'><strong>摘　　要：</strong>[目的]探讨胃脘痛胃黏膜异型增生患者中医微观辨证分型与CdX2基因蛋白表达的意义及与临床随访结果的关系。[方法]应用中医脏腑辨证理论与ABC免疫组化方法对120例胃脘痛胃黏膜异型增生患者进行胃镜下微观辨证分型与CdX2基因蛋白表达的免疫组化分析,同时进行临床随访研究。[结果]胃络瘀滞型与胃络灼伤型患者胃黏膜CdX2基因蛋白表达阳性率(37.5％、66.7％)较胃寒型与胃热型(6.7％、12.5％)明显增高(P<0.01),其中具有完整随访结果者63例,随访时间6-72个月(平均24个月),其癌变者中胃络瘀滞型(76.7％)明显高于未癌变者(27.3％)(P<0.01)。[结论]中医微观辨证分型与CdX2基因蛋白表达有关,对辨别胃黏膜异型增生的癌变性质具有重要意义,胃络瘀滞型胃黏膜异型增生与癌变关系密切,在辨证施治中应给予重视。<em><abstract>bjective] To study the relationship between microcosmic distinguish type of gastric precancerous lesions and the expression of CdX2 and its significance in follow - up study. [Methods] One hundred and twenty cases of gastric precancerous lesions (dysplasia and metaplasia) were microcosmic divided distinguishally into four types by endoscopies according to Zang - fu distinguish theory of traditional Chinese medicine. The expression of CdX2 was studied by ABC immunohistochemical method. [Results] The expression of CdX2 in the Type Gastric Net Resort (TGNR) and Gastric Net Burn (TGNB)(37.5 % ,66.7 % ) were higher than that of the groups of Type Gastric Cold (TGC) and Type Gastric Hot ( TGH ) (6. 7 % , 12. 5 % ) ( P < 0. 01). Sixty-three cases were followed up for 6 to 72 months. There were 23 cases of TGNR in the 30 cases of cancer formation group, but 9 in 33 cases of no cancer formation group ( P < 0. 01). [Conclusion] The gastric precancerous lesions (dysplasia and metaplasia ) with TGNR have a close relationship to cancer formation, and need to pay more attention in the distinguish treatment.</em></p><p class='subject'><strong>关 键 词：</strong><a href='/subject/article.aspx?id=3900798' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=K%3d%5b%e8%83%83%e8%84%98%e7%97%9b%5d' title='胃脘痛'>胃脘痛</a> <a href='/subject/article.aspx?id=1008583' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=K%3d%5b%e5%bc%82%e5%9e%8b%e5%a2%9e%e7%94%9f%5d' title='异型增生'>异型增生</a> <a href='/zk/search.aspx?key=K%3d%5b%e8%be%a8%e8%af%81%e5%88%86%e5%9e%8b%5d' title='辨证分型'>辨证分型</a> <a href='/subject/article.aspx?id=8259867' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=K%3d%5bCDX2%e5%9f%ba%e5%9b%a0%5d' title='CDX2基因'>CDX2基因</a> </p><p class='class'><strong>分 类 号：</strong><a href='/zk/search.aspx?key=C%3dR256.33' title='R256.33'>R256.33</a>[<a href = '/domain/article.aspx?id=456' >医药卫生—中医内科学</a>] <a href='/zk/search.aspx?key=C%3dR241' title='R241'>R241</a>[<a href = '/domain/article.aspx?id=451' >医药卫生—中医学</a>] </p> </div> <div id="content_wzxg" name="wzxg" class="article-graph"> <object width="695" height="250" classid="clsid:D27CDB6E-AE6D-11cf-96B8-444553540000" id="FlashID"> <param value="../flash/relation.swf" name="movie"> <param value="high" name="quality"> <param value="opaque" name="wmode"> <param value="6.0.65.0" name="swfversion"> <param value="dataUrl=/ajax/articlerelativegraph.ashx?id=10880167" name="flashVars"> <embed width="695" height="250" src="../flash/relation.swf" type="application/x-shockwave-flash" quality="high" wmode="opaque" flashvars="dataUrl=/ajax/articlerelativegraph.ashx?id=10880167"> </embed> </object> </div> <div class="article-relate-list"> <div class="relate-list"> <p id="ckwx_br"> </p> <h2 name="ckwx" id="ckwx">参考文献：</h2> <div id="listckwx"> <p class='submit'> <img src='/images/loading.gif' width='16' height='16' /> 正在载入数据... </p> </div> </div> <div class="relate-list"> <p id="2jckwx_br"> </p> <h2 name="2jckwx" id="2jckwx">二级参考文献：</h2> <div id="list2jckwx"> <p class='submit'> <img src='/images/loading.gif' width='16' height='16' /> 正在载入数据... </p> </div> </div> <div class="relate-list"> <p id="ohwx_br"> </p> <h2 name="ohwx" id="ohwx">耦合文献：</h2> <div id="listohwx"> <p class='submit'> <img src='/images/loading.gif' width='16' height='16' /> 正在载入数据... </p> </div> </div> <div class="relate-list"> <p id="yzwx_br"> </p> <h2 name="yzwx" id="yzwx">引证文献：</h2> <div id="listyzwx"> <p class='submit'> <img src='/images/loading.gif' width='16' height='16' /> 正在载入数据... </p> </div> </div> <div class="relate-list"> <p id="2jyzwx_br"> </p> <h2 name="2jyzwx" id="2jyzwx">二级引证文献：</h2> <div id="list2jyzwx"> <p class='submit'> <img src='/images/loading.gif' width='16' height='16' /> 正在载入数据... </p> </div> </div> <div class="relate-list"> <p id="tbywx_br"> </p> <h2 name="tbywx" id="tbywx">同被引文献：</h2> <div id="listtbywx"> <p class='submit'> <img src='/images/loading.gif' width='16' height='16' /> 正在载入数据... </p> </div> </div> <div class="relate-list"> <p id="xgqklw_br"> </p> <h2 name="xgqklw" id="xgqklw">相关期刊文献：</h2> <div id="listxgqklw"> <p class='submit'> <img src='/images/loading.gif' width='16' height='16' /> 正在载入数据... </p> </div> </div> </div> </div> <div class="article-about"> <div class="about-box"> <h5 class="name">相关的主题<tt><a class="hide" href="#"></a></tt></h5> <div class="about-list"> </div> </div> <div class="about-box"> <h5 class="name">相关的作者对象<tt><a class="" href="#"></a></tt></h5> <div class="about-list" style="display: none;"> </div> </div> <div class="about-box"> <h5 class="name">相关的机构对象<tt><a class="" href="#"></a></tt></h5> <div class="about-list" style="display: none;"> </div> </div> </div> </div> </div> <script type="text/javascript" src="/scripts/articlerelation.min.js"></script> <script type="text/javascript" src="/scripts/articlerightrelation.min.js"></script> <script type="text/javascript" src="/scripts/articledown.min.js"></script> <div class="layer-box download" id="downloadlayer" style="display: none"> <div class="close"> <a onclick="closedown()" href="javascript:void(0)"> <img src="/images/layer-close.png" width="21" height="21" alt="" /> </a> </div> <h5 class="layer-title">下载全文</h5> <div id="downloadinfo"></div> </div> <div class="layer-box download" id="downloadlayer2" style="display:none;min-height:100px;width:500px;"> <p> <img src="/images/loading2.gif" width="64" height="64"> <span style="font-size:20px;vertical-align:middle;padding-bottom:50px;">正在链接到云南高校图书馆文献保障联盟下载...</span> </p> </div> <script id="bdshare_js" data="type=tools&uid=0" type="text/javascript"></script> <script type="text/javascript"> $(function () { var rd = GetQueryString("rd"); 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