早期干预促进新生儿缺氧缺血性脑病患儿智力及行为发育的临床观察  

Clinical effect of early intervention on infants with hypoxic ischemic encephalopathy

作　　者：许丽芳 赵萍 周春梅 张伟忠 

机构地区：[1]广东省惠州市惠阳区保健院,516001

出　　处：《河北医药》2004年第11期857-858,共2页Hebei Medical Journal

摘　　要：目的　探讨早期干预对新生儿缺氧缺血性脑病 (HIE)患儿智力及行为发育的影响。方法　将 76例HIE患儿分为干预组 40例 ,对照组 3 6例 ;仅干预组接受早期干预 ,两组患儿接受相同的育儿知识 ,由专人定期进行体格发育与神经系统检查及智力测定。结果　干预组在 1岁和 2岁时智力发育指数 (MDI)为 10 0 .4± 12 .8、112 .2± 13 .1,运动发育指数 (PDI)为 97.8± 11.4、10 2 .6± 12 .6,明显高于对照组 ( 91.5± 13 .8、10 1.5± 14 .0和 85 .6± 13 .2、91.3± 15 .1) ,差异非常显著 (P <0 .0 1) ;干预组脑瘫、智力低下、癫痫发生例数明显低于对照组 ,差异亦非常显著 (P <0 .0 1)。结论　对HIE患儿进行早期干预可改善其智力及行为发育 ,减少伤残 ,降低脑瘫。Objective To investigate the clinical effect of early intervention on intelligential and physical development in infants with hypoxic ischemic encephalopathy (HIE).Methods 76 infants with HIE were divided into intervention group (n=40) and control group (n=36).Early intervention was applied in intervention group.All the infants accepted the same education as other children did.The physical and neurological conditions and intelligence test were studied regularly.Results At the age of 1 year and 2 years,the mental development index (MDI) of intervention group was 100.4±12.8 and 112.2±13.1 respectively,the physical development index (PDI) was 97.8±11.4 and 102.6±12.6 respectively.The parameters were significantly higher than those of the control group (MDI:91.5±13.8, 101.5±14.0;PDI:85.6±13.2,91.3±15.1)(P<0.01).The incidence of cerebral palsy,disability and epilepsy was significantly lower in intervention group than that in control group (P<0.01).Conclusion Early intervention for the infants with HIE can improve their intelligential and behavior development,and reduce the incidence of disability,cerebral palsy and epilepsy.

关 键 词：早期干预 患儿 行为发育 对照组 新生儿缺氧缺血性脑病 脑瘫 癫痫 智力测定 结论 指数 

分 类 号：R722.12[医药卫生—儿科] R179[医药卫生—临床医学]