中药“消症汤”对子宫内膜异位模型大鼠异位组织的影响  

EXPERIMENTAL STUDY OF THE RAT EMT MODEL TREATED WITH TRADITIONAL CHINESE MEDICINE XIAO ZHENG TANG

作　　者：徐邦生[1] 朱建华[2] 蔡云平[3] 李奕[3] 

机构地区：[1]南通医学院分子神经生物学江苏省重点实验室 [2]南通医学院附属医院中医科,南通226001 [3]南通医学院组织学与胚胎学教研室

出　　处：《解剖学报》2004年第5期521-525,共5页Acta Anatomica Sinica

基　　金：江苏省普通高校自然科学研究计划资助项目( 0 2KJD3 10 0 0 1) ;南通市社会发展计划项目(S2 0 3 6)

摘　　要：目的　观察活血化瘀方剂“消症汤”对植入在腹腔的子宫内膜异位组织的影响 ,为临床用药提供实验依据。　方法　制作大鼠子宫内膜异位 (endometriosis,EMT)动物模型 ,模型鼠每日以中药灌胃 ,用药后第 2、4、5周分别观察腹腔异位组织生长情况 ,在位子宫、异位子宫内膜、双侧卵巢的组织学变化并作图像分析。　结果　 0 5ml组和 1 0ml组用药 4周 ,1 5ml组用药 2周异位组织基本消退。切片观察用药后异位组织周围血管丰富 ,异位内膜减少 ,异位腺上皮变矮 ,腺细胞核固缩。　结论　“消症汤”能抑制异位内膜增生 ,促进炎症包块消退。Objective To study the therapeutic effects of traditional Chinese medicine(Xiao Zheng Tang) on endometriosis(EMT) model rats. Methods Firstly, to reproduce rat endometriosis model, secondly, three weeks after operation, EMT model rats were randomly divided into 4 groups:3 experimental groups and 1 control group. Experimental groups were poured Chinese medicine down the throat with Xiao Zheng Tang 0.5ml,1.0ml,1.5ml respectively every day and the control group was treated with 1.0ml H 2O for every rat. Thirdly, to observe the changes of the normal and transplanted endometrium on the 2nd, 4th and 5th week after therapy. Results With the time extending, decreased number of the survived graft, shortened height of epithelium and atrophy of the nucleus of the glandular cells were shown in all experimental groups except for control group. On the 4th week after therapy the graft disappeared in 0.5ml and 1.0ml groups or 1.5ml group on the 2nd week.Conclusion Xiao Zheng Tang inhibits growth of the graft and showed a significant therapeutic effects on EMT model rat.

关 键 词：活血化瘀中药 子宫内膜异位 动物模型 图像分析 大鼠 

分 类 号：R329.4[医药卫生—人体解剖和组织胚胎学]