竹黄颗粒剂Ⅱ号对寻常性银屑病皮损MMP-2 TIMP-2的影响  

Effects of Zhuhuang Granule-II on the Detection of MMP-2 and TIMP-2 in Lesions of Psoriasis Vulgaris

作　　者：向亚平[1] 陈晋广 杨志波[3] 欧阳恒[3] 

机构地区：[1]中南大学湘雅三院皮肤科,湖南长沙410013 [2]浙江台州市市立医院皮肤科,浙江台州318000 [3]湖南中医学院附二医院皮肤科,湖南长沙410004

出　　处：《中国皮肤性病学杂志》2004年第11期662-664,共3页The Chinese Journal of Dermatovenereology

摘　　要：目的探讨竹黄颗粒剂II号治疗寻常性银屑病作用机制。方法采用免疫组化ABC法检测患者口服竹黄颗粒剂II号前、后皮损中MMP2和TIMP2阳性强度,并与银屑灵冲剂组对照。结果治疗后两组患者皮损MMP2和TIMP2阳性水平均显著下降(P均<0.01);且竹黄组优于银屑组(P<0.05)。结论竹黄颗粒剂II号是治疗寻常性银屑病的有效复方,显著降低寻常性银屑病患者皮损中MMP2和TIMP2的阳性水平可能是其作用机制之一。Objective To explore the therapeutic mechanism of Zhuhuang Granule II. Methods To compare MMP 2 and TIMP 2 detection in the lesions of patients with immunohistochemical technique Avidin Biotin comples (ABC) before and after treatment,and 15 normal controls.Results The MMP 2 and TIMP 2 of all cases in both of the ZHG II group and Yinxie group decreased after treating,but the improvement in ZHG II group was more remarkable than that in Yinxie group( P <0.01).Conclusion These functions are partially effective mechanism of ZHG II.

关 键 词：银屑病 竹黄颗粒剂Ⅱ号 基质金属蛋白酶-2 基质金属蛋白酶组织抑制因子-2 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]