细梗香草中的两个新三萜皂苷  

Two new triterpenoid saponins from Lysimachia capillipes Hemsl.

作　　者：田景奎[1] 邹忠梅[1] 徐丽珍[1] 许莉[2] 张宏武[1] 穆红梅[1] 谢忱[1] 杨世林[1] 

机构地区：[1]中国医学科学院,中国协和医科大学药用植物研究所,北京100094 [2]北京微量化学研究所,北京100060

出　　处：《药学学报》2004年第9期722-725,共4页Acta Pharmaceutica Sinica

摘　　要：目的 对细梗香草(Lysimachia capillipes Hemsl.)全草的三萜皂苷成分进行分离和结构鉴定。方法 通过大孔树脂纯化,硅胶和反相硅胶色谱分离正丁醇萃取物中的三萜皂苷;利用多种波谱技术并结合酸水解方法鉴定其化学结构。结果 分离鉴定了2个三萜皂苷,其结构分别为3β,22α-二羟基-16α-当归酰氧基-28→13-内酯-齐墩果烷-3-O-[β-D-吡喃葡糖基-(1→2)-α-L-吡喃阿拉伯糖基]-22-O-(6-乙酰基)-β-D-吡喃葡糖苷(Ⅰ),3β,13β,22α-三羟基-16α-乙酰氧基-齐墩果烷-28羧酸钠-3-O-[β-D-吡喃葡糖基-(1→2)-α-L-吡喃阿拉伯糖基]-22-O-β-D-吡喃葡糖苷(Ⅱ)。结论 化合物Ⅰ和Ⅱ为新的三萜皂苷,分别命名为细梗香草皂苷Ⅰ和细梗香草皂苷J。Aim To study the triterpenoid saponins in the whole plants of Lysimachia capillipes Hemsl. . Methods Column chromatography (including AB-8 macroporous resin, silica gel and ODS) was used to separate triterpenoid saponins whose structures were elucidated by ESI-MS, NMR (1D and 2D) and hydrolysis methods. Results Two new triterpenoid saponins were isolated and established as 3β, 22α-dihydroxy-16α-angeloyloxy-28 →13-lactone-oleanane-3-O-[bβ-D-glucopyranosyl-( 1→2 )-α-L-arabinpyranosyl]-22-O-( 6-acetyl)-β-D-glucopyranoside (Ⅰ), 3β, 13β, 22α-trihydroxy-16α-acetyloxy-oleanane-28-oic acid Na-3-O-[β-D-glucopyranosyl-( 1→2 )-α-L-arabinpyranosyl ]-22-O-β-D-glucopyranoside (Ⅱ). Conclusion Compounds Ⅰ and Ⅱ are new compounds and named as capilliposide Ⅰ and capilliposide J.

关 键 词：细梗香草 三萜皂苷 细梗香草皂苷Ⅰ 细梗香草皂苷J 

分 类 号：R284.1[医药卫生—中药学] R284.2[医药卫生—中医学]