炎琥宁注射液与氨茶碱配伍的稳定性考察  

A Study of the Stability of Compatibility of Injectio Natrii Kalii Dehydroandrographolidi Succinas with Aminophylline Injection in Normal Saline

作　　者：张汉利 石静[2] 魏友霞[2] 罗俊[2] 

机构地区：[1]深圳万乐药业有限公司开发部,518029 [2]西安交通大学第一医院药剂科,710061

出　　处：《医药导报》2004年第12期961-962,共2页Herald of Medicine

摘　　要：目的 :考察室温下 ,炎琥宁注射液与氨茶碱在 0 .9%氯化钠溶液中的配伍稳定性。方法 :采用新Vierordt法测定炎琥宁与氨茶碱在 0 .9%氯化钠溶液中配伍 2 4h内各时间段的含量 ,同时测定pH值、微粒 ,观察配伍液的外观变化。结果 :室温 4h内 ,炎琥宁与氨茶碱配伍后pH值、微粒、含量均无明显变化 ,但溶液呈淡黄色 ;6h时 ,炎琥宁含量、pH值、微粒变化较大 ,配伍液呈黄色。结论 :炎琥宁注射液与氨茶碱可在 0 .9%氯化钠溶液中配伍 ,但应现配现用 ,并且应在配伍后 4h内使用。Objective:To study the stability of compatibil ity of injectio natrii kalii dehydroandrographolidi succinas with aminophylline injection in normal saline (NS) at room temperature. Methods:New Vierordt's method was adopted to determine a t room temperature the contents of Sodium Potassium Dehydroandrographolide Succi nate and aminophylline coexisting in NS at various time periods within 24 h. The outward appearance of the solution was kept under observation and the pH value, numbers of particles were determined. Results:Within 4 hours at room temperature, no obvious c hanges in the pH value, particle number and contents of both drugs were demonstr ated .The solution, however, turned light yellow in color .At the 6 th hour , relatively major changes appeared in the content of Sodium Potassium Dehydroan drographolide Succinate, pH value and particle number. The solution then became yellow in color. Conclusion:Sodium potassium dehydroandrographolide succi nate was shown to be compatible with aminophylline in NS. It is important, howev er, that the solution should be used within 4 h after mixing of the two drugs in NS.

关 键 词：炎琥宁 氨茶碱 配伍 稳定性 

分 类 号：R927.11[医药卫生—药学] R286