环宁片对离体大鼠子宫平滑肌收缩活动的影响  

Effect of Huangning-Tablet on Contraction Activity of Isolated Rat-uterine Smooth Muscle

作　　者：文乐兮[1] 尤昭玲[1] 雷磊[1] 贺林[1] 付灵梅[1] 

机构地区：[1]湖南中医学院,湖南长沙410007

出　　处：《中国实验方剂学杂志》2004年第6期39-42,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家中医药管理局科研基金项目 0 2- 0 3JL0 7

摘　　要：目的 :探讨环宁片治疗铜宫内节育器 (Cu IUD)所致子宫异常出血的作用机理。方法 :以黄体酮和缩宫素作对照 ,观察大鼠子宫平滑肌的收缩活动。结果 :环宁片对大鼠子宫平滑肌有不同程度的增强作用 ,但对由缩宫素引起的子宫平滑肌强烈收缩有明显的对抗作用。结论 :环宁片对子宫平滑肌的收缩力起到双向性的调节作用 ,从而改善子宫平滑肌的病理状态 ,达到止血的目的。Objective:To investigate the effective mechanism of Huangning-Tablet for abnormal uterine hemorrhage caused by copper intrauterine device(Cu-IUD).Methods:Observing Huangning-Tablet-induced contraction activity of rat-uterine smooth muscles in comparison with that caused respectively by progesterone and oxytonin.Results:Huangning-Tablet can,to different extent,strengthen this contraction and it also has obvious resistance to the strong contraction brought about by oxytocin.Conclusion:Huangning-Tablet has dual-direction function of regulating the contractility of uterine smooth muscle,and consequently improves pathological state and exerts haemostatic function.

关 键 词：环宁片 宫内节育器 子宫出血 大鼠 子宫收缩活动 

分 类 号：R285.5[医药卫生—中药学]