Bcl-2/Fas与子宫内膜异位症发病关系的研究  

Relation between Bcl-2/Fas gene and pathogenesis of endometriosis

作　　者：毛熙光[1] 林海蕤[1] 高谨[1] 秦明丽[1] 邱盛洪[1] 

机构地区：[1]四川泸州医学院附属医院妇产科,四川泸州646000

出　　处：《中国现代医学杂志》2004年第22期57-58,70,共3页China Journal of Modern Medicine

摘　　要：目的研究Bcl-2/Fas基因蛋白与子宫内膜异位症的发病关系。方法用免疫组化ABC法检测了40例正常子宫内膜和46例子宫内膜异位症患者。结果子宫内膜异位症患者的内膜组织中的表达评分(172.4±87.6)明显高于正常子宫内膜中的表达评分(106.2±118.1),有显著性差异(P<0.05);Fas基因蛋白在子宫内膜异位患者异位内膜细胞中的表达评分(207.6±100.2)与正常子宫内膜上皮中的表达评分(119.3±91.3)无显著性差异(P>0.05)。结论Bcl-2基因与子宫内膜异位症的发生有一定关系,Fas基因对子宫内膜异位症的发生关系有待于进一步研究。Objective:To research whether the endometriosis is associated with Bcl-2and Fas gene.Methods:Immunohistochemisty me test(ABC methods)was used to detect the expression of Bcl-2and Fs gene in40speci-mens of normal endometrium tissue and46specimens of endometriosis tissue.Results:In the endometriosis group,the positive rate of Bcl-2gene was significantly higher than that of the normal endometrium group(P<0.05);the rate of Fas gene was no significantly difference with that of the normal group(P>0.05).Conclusions:The study sug-gestes that Bcl-2gene is relate with endometriosis;more study should be done to find the relation between Fas gene and endometriosis.

关 键 词：子宫内膜异位症 细胞凋亡 基因表达 BCL-2 FAS 

分 类 号：R711.71[医药卫生—妇产科学]