沐舒坦对急性肺损伤肺保护作用的研究  

Study of predictive effect of ambroxol on acute lung injury

作　　者：赵中江[1] 孟新科[1] 杨径[1] 

机构地区：[1]深圳市第二人民医院急诊科,广东深圳518035

出　　处：《中国现代医学杂志》2004年第22期106-108,共3页China Journal of Modern Medicine

摘　　要：目的研究沐舒坦对急性肺损伤的肺保护作用。方法75例急性肺损伤病人随机分为常规治疗组(37例)和沐舒坦治疗组(38例),沐舒坦治疗组在常规治疗基础上加用沐舒坦1g/d静滴3d。两组病人治疗前后分别测定血液中的IL-6,IL-8和TNF-a浓度;动脉血气分析;SIRS评分。比较上述指标组内治疗前后以及两组之间的差异;两组病人ARDS的发病率和死亡率的差异。结果沐舒坦治疗3d后,病人血液中IL-6,IL-8和TNF-a浓度明显降低,动脉血气分析改善较常规组更明显,SIRS评分较治疗前和常规组均明显降低(P<0.05);而常规治疗组虽然动脉血气有明显改善(P<0.05),但炎症介质浓度和SIRS评分则改变不明显(P>0.05)。沐舒坦治疗组ARDS的发病率(13.5%)和死亡率(0)均明显低于常规治疗组(39.7%;8.1%)(P<0.05)。结论沐舒坦能在一定程度上抑制炎症介质的释放,减少急性肺损伤患者ARDS的发生率,降低其病死率,有良好的肺保护作用。Objective:To study the predictive effect of ambroxol on acute lung injury.Methods:75pa-tients with acute lung injury were enrolled in study and randomly divided into two groups.One groups was served as general treatment group,included37patients who received high frequency oscillatory ventilation(HFO),another was served as ambroxol treatment group included38patients who received ambroxol(1g/d ivgtt×3d)treatment with HFO.Concentrations of IL-6,IL-8,TNF-a,parameters of blood gas dialysis and SIRS scores were compared between before and after treatment inter the two groups respectively;them also were compared between the two groups after treatment.Incidences of ARDS and mortality rates were also were compared between the tow groups after treatment respectively.Results:After treatment with ambroxol3days,concentrations of IL-6,IL-8,TNF-a,and SIRS score were decreased significantly(P<0.05);parameters of blood gas dialysis were also improved significantly(P<0.05),compared to before treatment in ambroxol treatment group.Although parameters of blood gas dialysis were also improved significantly(P<0.05),Concen-trations of IL-6,IL-8,TNF-a,parameters of blood gas dialysis and SIRS score hadn't significantly changes in general treatment group(P>0.05).All of the parameters were changed significantly in ambroxol treatment group compared to general treatment group(P>0.05).Incidence of ARDS(13.5%)and mortality rate(0)in ambroxol treatment group were under than that of general treatment group(39.7%for incidence of ARDS;8.1%for mortality rate).Conclusions:Ambroxol can restrain release of inflammatory dedia in ALI patients.Incidence of ARDS and mortality rate can be decreased in ALI patients treated with ambroxol.It clues to us that ambroxol maybe have good predictive effect on ALI patients.

关 键 词：急性肺损伤 急性呼吸窘迫综合征 沐舒坦 

分 类 号：R563.8[医药卫生—呼吸系统]