端粒酶在胃癌和癌前病变中的表达及相关性研究  

STUDY ON THE EXPRESSION OF TELOMERASE IN GASTRIC CANCER AND PRECANCEROUS LESIONS

作　　者：齐洁敏[1] 高福禄[1] 陈龙[1] 李韬[2] 梅立新[1] 

机构地区：[1]承德医学院,河北承德067000 [2]承德医学院附属医院

出　　处：《承德医学院学报》2004年第4期278-280,共3页Journal of Chengde Medical University

摘　　要：目的 :探讨胃癌及癌前病变中端粒酶 (hTERT)的表达及临床意义。方法 :采用原位杂交方法 ,检测了 130例石蜡包埋标本。结果 :1.端粒酶 (hTERT)主要分布在细胞浆中 ,在慢性浅表性胃炎 (CSG)、慢性萎缩性胃炎 (CAG)、非典型增生 (DYS)及胃癌 (GC)中表达率分别是 0 %、10 %、30 %、78.75 %。在GC中表达率最高 ,GC组中的端粒酶与CSG、CAG、DYS相比P <0 .0 1。 2 .80例胃癌中 ,端粒酶在高分化、中分化、低分化癌中表达率分别为 71.4 3% ,75 % ,75 % ,各组之间无差异性 (P >0 .0 5 )。结论 :端粒酶的表达与胃癌的发生密切相关。端粒酶检测对胃癌诊断具有重要意义 ,是一个很好的恶性肿瘤标记物 ;端粒酶表达强度与胃癌的分化程度无相关性。Objective:To study the expression of telomerase (hTERT) in gastric cancer, precancerous lesions and its clinical signicance. Methods: In situ hybridization was used in this study and 130 paraffin-imbedded specimens had been detected. Results: 1. Telomerase was mainly distributed in plasm, the positive rate was 0%, 10%, 30% and 78.75% in CSG,CAG,DYS and GC respectively. The positive rate in GC was the highest (compared with CSG, CAG and DYS:P<0.01). 2 .In 80 gastric cancers, the positive rate of telomerase in higher, medium and lower differatiantion cancer was 71.43%, 75%, 75% respectively, there was no difference among them (P>0.05). Conclusions: Telomerase has close relations with gastric cancer . The detection of telomerase is very important to the diagnosis of gastric cancer and it is a much better marker to malignant tumor. The expession of telomerase has no relations with the differentiation of gastric cancer.

关 键 词：胃癌 癌前病变 端粒酶 原位杂交 

分 类 号：R735.2[医药卫生—肿瘤]