胰岛自身抗体与1型糖尿病  

Islet autoantibodies and type 1 diabetes mellitus

作　　者：董维平[1] 胡远峰[1] 王煜非[1] 张爱芳[1] 王丽娟[1] 

机构地区：[1]上海市第一人民医院糖尿病研究室,200080

出　　处：《中华内分泌代谢杂志》2003年第4期287-288,共2页Chinese Journal of Endocrinology and Metabolism

摘　　要：　 1617例糖尿病患者中自身抗体阳性率 2 9.7%。单一抗体的阳性率明显低于 3种抗体联合检测。多种胰岛自身抗体联合检测可提高 1型糖尿病早期诊断的敏感性。谷氨酸脱羧酶抗体为成年糖尿病患者预示胰岛素依赖的较好的筛查试验 ,与酪氨酸蛋白磷酸酶抗体联合检测可达近 10 0 %的预报价值 ;而青少年糖尿病患者则还需检测胰岛细胞抗体。The positive rate of autoantibodies was 29.7% in 1617 diabetic patients. The positive rate of monoautoantibody was lower than that of combined assay with 3 autoantibodies. Combined assay of multiple autoantibodies may enhance the positivity of early diagnosis of type 1 diabetes mellitus. Glutamic acid decarboxylase antibody (GADA) may be a better screening test for predicting insulin dependency, the prediction of GADA combined with protein tyrosine phosphatase antibody may approximate to 100%, whereas islet cell antibody assay may be needed in the adolescent patients.

关 键 词：胰岛自身抗体 1型糖尿病 谷氨酸脱羧酶抗体 胰岛素依赖 

分 类 号：R587.1[医药卫生—内分泌]