血清真胰岛素与免疫反应性胰岛素、C肽的相关性分析  

Correlation analysis of serum true insulin, immunoreactive insulin and immunoreactive C peptide

作　　者：马博清[1] 宋光耀[1] 叶蔚[1] 薛树正[1] 张文杰 王智华 

机构地区：[1]河北省人民医院老年医学研究所内分泌科,石家庄050071 [2]河北省老年医学重点实验室

出　　处：《中华内分泌代谢杂志》2003年第4期291-292,共2页Chinese Journal of Endocrinology and Metabolism

摘　　要：按口服葡萄糖耐量试验结果将研究对象分为糖耐量正常组 ( 75例 ) ,糖耐量低减组 ( 4 3例 )和2型糖尿病组 ( 5 4例 )。在这些不同糖耐量对象测定空腹血糖 ,真胰岛素 (TI) ,免疫反应性胰岛素 (IRI)和免疫反应性C肽 (IRC)并计算胰岛 β细胞功能指数HOMA β。结果显示TI能真实反应血中胰岛素水平 ;随着胰岛 β细胞功能减退 ,IRI与TI的相关性逐渐降低 ,IRC与TI在各不同糖耐量人群均有明显的相关性。提示在反映胰岛 β细胞功能方面IRC优于IRI。The subjects were divided into groups with normal glucose tolerance (n=75), impaired glucose tolerance (n=43) and type 2 diabetes (n=54) according to oral glucose tolerance test. Fasting blood glucose, true insulin (TI), immunoreactive insulin (IRI) and immunoreactive C-peptide (IRC) were assayed in individuals of each group and HOMA-β was calculated. The results showed that TI truely reflected blood insulin level; as the islet β cell function was decreasing, the correlation between IRI and TI was gradiently declined; the significant correlation between IRC and TI was shown in these 3 groups. These results suggest that IRC is better than IRI in evaluating β cell function.

关 键 词：血清 真胰岛素 免疫反应性胰岛素 C肽 相关性分析 非胰岛素依赖型糖尿病 

分 类 号：R446.6[医药卫生—诊断学] R[医药卫生—临床医学]