糖尿病性心肌病变凋亡相关新基因2ass-bnip3的电子克隆及其功能预测  

Electronic cloning and functional prediction of new apoptosis related gene 2ass-bnip3 of diabetic cardiomyopathy

作　　者：张芳林[1] 李果[1] 谢超[1] 张迪[1] 周文中[1] 许光武[1] 陈刚[1] 孙卫华[1] 罗敏[1] 

机构地区：[1]上海第二医科大学附属瑞金医院内分泌代谢科,上海市内分泌代谢病研究所200025

出　　处：《中华内分泌代谢杂志》2003年第4期325-326,共2页Chinese Journal of Endocrinology and Metabolism

基　　金：国家 973项目 (G1 9980 51 0 1 7);国家自然科学基金(30 1 0 0 0 85);罗氏国际合作项目基金 (2 0 0 1年 )共同资助

摘　　要：对应用荧光标记的mRNA差异显示分析技术筛选获得的 2型糖尿病性心肌病变凋亡相关新基因 2ass bnip3 ,进行全长克隆及其结构 /功能预测 ,获得 15 94bp的新基因全长及其编码的具 187个氨基酸的蛋白 2ass bnip3 p ,它可能通过钙调 凋亡调节通路而在糖尿病心肌病变的发生中发挥重要作用。Using the technique of fluorescent-labled mRNA differential display, new apoptosis related gene 2ass-bnip3 of type 2 diabetic cardiomyopathy was found, the sequence of 1594 bp with coding 187 amino acids was obtained by the full-length clone, and its structural and functional predictions were performed. 2ass-bnip3 may play an important role in the development of diabetic cardiomyopathy via a regulatory pathway of calcium regulation and apoptosis.

关 键 词：糖尿病性心肌病变 2ass-bnip3 电子克隆 功能 预测 

分 类 号：R587.2[医药卫生—内分泌]