血管紧张素系统基因多态性与阻塞性睡眠呼吸暂停低通气综合征  

Association of polymorphisms in the angiotensin system genes with obstructive sleep apnea-hypopnea syndrome

作　　者：张立强[1] 姚婉贞[1] 何权瀛[2] 王玉柱[1] 任斌[1] 林亚萍[1] 

机构地区：[1]北京大学第三医院呼吸科,100083 [2]北京大学人民医院呼吸科

出　　处：《中华结核和呼吸杂志》2004年第8期507-510,共4页Chinese Journal of Tuberculosis and Respiratory Diseases

摘　　要：目的 探讨血管紧张素转换酶(ACE)和血管紧张素原(AGT)基因与阻塞性睡眠呼吸暂停低通气综合征(OSAHS)发病的关系。方法 应用聚合酶链反应(PCR)和限制性长度多态性方法测定无亲缘关系的中国北方汉族男性121例OSAHS患者与100例非OSAHS对照者的ACE和AGT基因多态性的基因型,并检验两组基因型的分布、等位基因频率的差异和基因多态性对OSAHS患者组肥胖表型的效应,分析基因型与睡眠呼吸暂停低通气指数(AHI)、收缩压(SBP)与舒张压(DBP)的关系。结果 ACE基因多态性的基因型分布两组差异无显著性(P>0.05),OSAHS患者组AGT基因多态性的基因型分布和等位基因频率与对照组相比,差异有显著性(P<0.05),OSAHS患者组中AGT基因多态性T等位基因携带者的体重指数(BMI)、颈围(NC)、腰臀比(WHR)明显高于非携带者,AHI、SBP与DBP也相应明显高于非携带者,差异有显著性(P<0.05)。结论 ACE I/D基因多态性可能不参与中国北方汉族男性中心型肥胖及OSAHS的形成。AGT基因多态性可能通过中心型肥胖而导致中国北方汉族男性OSAHS的发生及OSAHS患者高血压的形成。Objective To investigate the association of polymorphisms in the angiotensin system gene with obstructive sleep apnea-hypopnea syndrome (OSAHS) . Methods The genotypes and alleles of angiotensin-converting enzyme(ACE) and angiotensinogen(AGT) genes were identified by polymerase chain reaction-restricted fragment length polymorphism assay in 221 unrelated subjects of the north region 'Han' population of China (including 121 OSAHS subjects and 100 non-OSAHS subjects). The genotypes and allele frequencies of the polymorphisms were compared between OSAHS group and non-OSAHS group. The effects of the polymorphisms in OSAHS group on body mass index (BMI) , neck circumference ( NC ) , waist/ hip rate(WHR) , apnea-hypopnea index (AHI) , systolic blood pressure (SBP) , and diastolic blood pressure (DBF) were analysed. Results There were significant differences in genotypes distribution in AGT polymorphism between the two groups (P =0.009 ) . Compared with the control group, OSAHS group had significantly higher T allele frequency in AGT polymorphism(P=0.020). There were independent effects of AGT polymorphism on BMI, NC, WHR in OSAHS group, and carriers of the T allele of AGT polymorphism had greater BMI, NC, and WHR, while the carriers of the T allele had greater AHI, SBP, and DBP. Conclusions ACE polymorphism may not be correlated with central obesity and OSAHS in the population. AGT polymorphism may be involved in the development of central obesity and may be related to OSAHS and hypertension in OSAHS patients by the central obesity in male OSAHS subjects of North region ' Han' population of China.

关 键 词：血管紧张素转换酶 血管紧张素原 阻塞性睡眠呼吸暂停低通气综合征 基因多态性 

分 类 号：R56[医药卫生—呼吸系统]