高血压及高血压合并糖尿病患者血管内皮舒张功能的改变及缬沙坦干预  

Effect of valsartan on endothelium-dependent relaxing function in hypertensive patients with and without type 2 diabetes mellitus

作　　者：汤宝鹏[1] 曹桂秋[1] 马依彤[1] 穆玉明[2] 韩伟[2] 李晋新[1] 李晓梅[1] 孙惠萍[1] 

机构地区：[1]新疆医科大学一附院心内科,乌鲁木齐市830054 [2]新疆医科大学一附院心脏超声诊断科,乌鲁木齐市830054

出　　处：《中华心血管病杂志》2004年第7期600-602,共3页Chinese Journal of Cardiology

摘　　要：目的 探讨高血压及高血压合并糖尿病患者血管内皮依赖性舒张功能的变化及缬沙坦的干预作用。方法 采用高分辨超声技术,对34例高血压病(EH)及28例EH合并2型糖尿病(2DM)患者服用缬沙坦前及12周后右肱动脉反应性充血后内径变化率(△D％)进行检测。结果治疗前EH组与合并组(EH+2DM组)间右肱动脉基础内径(D0)差异无统计学意义,但EH+2DM组的△D％[(2.50±4.00)％]较EH组[(6.34±4.34)％]明显减低(P<0.05),服用缬沙坦治疗12周后,EH及EH+2DM组的△D％[(10.12±4.68)％、(4.68±3.22)％]均较治疗前明显改善(P<0.05)。结论 EH+2DM组较EH组患者存在更为严重的血管内皮依赖性舒张功能障碍,缬沙坦对二者的血管内皮损害具有明显的改善作用。Objective To investigate the changes of endothelium - dependent relaxing function in hypertensive patients with and without type 2 diabetes mellitus ( EH + DM vs. EH) and the effect of valsartan on it. Methods With high-resolution ultrasound, the change of diameters in brachial arteries in responding to reactive hyperemia (ΔD% ) were measured in 34 patients with EH and 28 patients with EH + DM pre and post treatment of valsartan. Results In patients with EH + DM, the ΔD% was much reduced compared with that in EH group [ ( 2. 50±4. 00 ) % vs. ( 6. 34± 4. 34 ) % , P < 0. 05] , while after being treated with valsartan for 12 weeks, the ΔD% was ameliorated than that pre treatment [ (4. 68±3. 22)% vs. (2.50±4.00)%, (10.12±4.68)% vs. (6.34±4.34)% , P <0. 05]. Conclusion Hypertensive patients with type 2 diabetes mellitus suffered more serious functional impairment of endothelium-dependent vasodilation than those without type 2 diabetes mellitus, and these dysfunction may be ameliorated by treatment of valsartan.

关 键 词：高血压 糖尿病 血管内皮舒张功能 缬沙坦 

分 类 号：R544.1[医药卫生—心血管疾病]