硅凝胶乳房假体包膜组织学研究  

Histologic features of capsule in breast implant

作　　者：杨维琦[1] 杨佩瑛[2] 范金财[2] 栾杰[2] 张旭辉[2] 朱志祥[1] 

机构地区：[1]深圳市第二人民医院整形烧伤科,深圳518035 [2]中国医学科学院整形外科医院

出　　处：《中华医学美学美容杂志》2004年第4期222-225,共4页Chinese Journal of Medical Aesthetics and Cosmetology

摘　　要：目的　通过动物实验 ,以了解硅凝胶乳房假体包膜中胶原组织学特点。方法　 30只大白兔 ,每只大白兔背部两侧肌层下随机各置入 10ml硅凝胶假体 1个。 3周、1、2、3、6、12个月时分别将包膜和假体完整地取出 ,在光学显微镜下测量包膜厚度 ,取包膜样本做成石蜡切片 ,进行HE染色、James染色、维多利亚蓝、丽春红复合染色和天狼猩红染色 ,光学显微镜下观察比较包膜特点 ,其余包膜样本进行胶原分型和含量测定。结果　⑴假体组织学特点 :大致可分为两层 ,包膜外层为疏松结缔组织 ,内层为致密结缔组织。包膜厚度在 3个月前逐渐增加 (P <0 .0 1) ;置入时间越长 ,假体包膜胶原成分越多、细胞成分越少 ,包膜越厚 (P <0 .0 1) ;3个月后 ,趋于稳定 (P >0 .0 5 )。⑵包膜胶原总量在 3个月前逐渐增高(P <0 .0 1) ;3个月后趋于稳定 (P >0 .0 5 )。⑶ 3个月前 ,包膜中胶原纤维最多 ,网状纤维次之 ,弹力纤维最少甚至无 ;,3个月后趋于稳定。⑷ 3个月前 ,包膜Ⅲ型胶原有减少趋势 ,Ⅰ型胶原有增多趋势 ;3个月后 ,均趋于稳定。结论　假体包膜在组织学上与瘢痕类似 。Objective To study the histologic characteristics of the capsule of breast implant. Methods Four miniprostheses were seperatelly implanted in four positions beneath the panniculus carnosus muscle in 30 rabbits. After 3 weeks, 1, 2, 3, 4, 6 and 12 months, capsular histology examination and the assay of capsular collagen content and type were performed. Results ⑴ Capsule was divided into two layers: the inner layer was dense and the outer loose connective tissues. Collagen component was more, cellular component was less and capsule was thicker (P<0.01) before 3 months. There were no significant changes after 3 months (P>0.05). ⑵ Capsular collagen content increased gradually in 3 months (P<0.01), and there were no significant change after 3 months (P>0.05). ⑶Collagen fibers were the most component, reticular fibers were second and elastic fibers were least. After 3 months, elastic fibers decreased, and collagen and reticular fibers became full layer gradually. ⑷ Capsular collagen type I in the capsule was gradually increased and type III decreased before 3 months. There were no significant changes after 3 months. Conclusions Histology of the implant capsule is similar to that of scar and the result of wound healing around implant.

关 键 词：硅凝胶 乳房假体 组织学特点 纤维包膜 胶原 隆乳术 

分 类 号：R655.8[医药卫生—外科学]