β-内啡肽在复杂性高热惊厥中的作用及纳洛酮的治疗作用  

The role of β-endorphin (β-EP) in children with complicated febrile convulsion and the therapeutic effect of Naloxone

作　　者：何莉[1] 陈继红 

机构地区：[1]广东医学院附属福田人民医院儿科,518033 [2]暨南大学医学院附属深圳市人民医院儿保科,518020

出　　处：《中国妇幼保健》2004年第9期66-67,共2页Maternal and Child Health Care of China

摘　　要：目的 :探讨 β-内啡肽 ( β- EP)在复杂性高热惊厥发病中的作用及纳洛酮治疗效果。方法 :将 5 5例复杂性高热惊厥 ( complicated febrile convulsion,CFC)患儿随机分为纳洛酮治疗组和常规治疗组 ,两组常规治疗方法相同 ,治疗组加用国产盐酸纳洛酮 ,按每次 0 .0 2～ 0 .0 4 mg·kg- 1 ,每 8h1次 ,连续使用 3～ 5 d。治疗前后对患儿的血浆和脑脊液 ( CSF)中 β- EP进行放射免疫测定 ,观察惊厥复发的次数和持续时间。结果 :治疗前治疗组与对照组之间血浆和脑脊液 β- EP无明显差别 ,P>0 .0 5。治疗后 5 d复查血浆和脑脊液 β- EP水平 ,纳洛酮组明显低于常规治疗组 ,两者比较差别有显著意义 ,P<0 .0 5。纳洛酮组所有患儿发热时均无惊厥再发作 ,脑电图好转。结论 :β-内啡肽 ( β- EP)与复杂性高热惊厥的发生密切相关 ,纳洛酮可以有效地阻断内源性阿片肽与阿片受体的结合 ,减少Objective:To investigate the role of β-endorphin in children with complicated febrile convulsion (CFC).Methods:55 cases of complicated febrile convulsion (CFC) were divided randomly into naloxone-treated group( n =28), and the routine-treated group( n =27).Both groups received routine therapy. The naloxone group received naloxone 0.02～0.04 mg· kg -1 every 8 hours a day and the period of treatment is 3 to 5 days. β-EP level of two groups in plasma and cerebrospinal fluid (CSF) were measured with radioimmunoassay before and after treatments .Observe the recurrence of febrile convulsion and the changes of electroencephalogram. Results:There were not significant differences between two groups in plasma and CSF β-EP before treatments( P >0.05 ).Plasma and CSF β-EP of naloxone-treated group were significantly lower than those of routine-treated group after 5 days( P <0.05). All patients in naloxone-treated group showed no recurrence of febrile convulsion and electroencephalogram improved. Conclusion:The are relationship between β--endorphin and the complicated febrile convulsion .CFC can be effectively treated with naloxone.

关 键 词：Β-内啡肽 复杂性高热惊厥 纳洛酮 治疗 小儿 

分 类 号：R720.597[医药卫生—急诊医学]