^(45)Ca标记复合钙化合物示踪钙生物动力学观察  

Radioisotope ^(45)Ca labeling four calcium chemical compounds and tracing calcium bioavailability

作　　者：郑辉[1] 甄荣[1] 牛惠生[2] 李怀芬[2] 

机构地区：[1]中国疾病预防控制中心辐射防护与核安全医学所,北京100088 [2]中国医学科学院中国协和医科大学放射医学研究所

出　　处：《中华放射医学与防护杂志》2004年第4期336-338,共3页Chinese Journal of Radiological Medicine and Protection

摘　　要：目的　用放射性核素4 5Ca标记 4种钙制剂化合物 ,并观察和示踪其生物利用度。方法用4 5Ca标记葡萄糖酸钙、柠檬酸钙、碳酸钙和L 苏糖酸钙 ,测定大鼠心、肝、脾、肾、脑、胃、肠、血液、粪便和尿中钙离子吸收含量和生物利用度。结果　① 4 5Ca标记的钙制剂具有较高的放射性活度、较稳定的组织标准曲线和回收率。②示踪 4种化合物生物利用度变化显示 ,有机钙化合物较无机钙化合物更利于组织的吸收。结论　4 5Ca标记钙制剂生物示踪方法具有灵敏、客观、准确和稳定的特点。Objective To build up a new method of the radioisotope 45 Ca labeling four calcium chemical compounds ,observe and tracing bioavailability change of calcium labeled with radioisotope 45 Ca. Methods The calcium gluconate(Ca-Glu),calcium citrinate(Ca-Cit),calcium carbonatte(Ca-Car) and calcium L-threonate(Ca-Thr)were labeled by radioisotope 45 Ca. Four calcium chemical compounds of 45 Ca labeling were used of calcium content 200 mg/kg in the rats and measure the absorption content and bioavailability of calcium in tissue of heart,lever spleen,stomach,kidney,brain,intestine,whole blood,urine,faeces. Results ① Radioisotope 45 Ca labeling calcium chemical compound has high radio intensity,more steady standard curve and recover rate. ② The absorption of organic calcium chemical compounds is higher than the inorganic calcium chemical compound in the study of calcium bioavailability. Conclusion The method of tracing with radioisotope 45 Ca labeling calcium chemical compounds has the characteristic of the sensitive,objective,accurate and steady in the study of calcium bioavailability.

关 键 词：^45Ca标记 钙化合物 钙生物 动力学 生物利用度 放射性标记 

分 类 号：Q691[生物学—生物物理学]